57) Hairy cell leukemia is positive for all common B-cell antigens (CD19, CD20, CD79a, FMC-7, and PAX5), with characteristic expression of annexin A1 (Figure 7, A), CD11c, CD25, CD103, CD123, DBA-44 (CD72) (Figure 7, B), the Hector Battifora mesothelial epitope-1 (HBME-1), pERK, Tbet, and TRAP58-61 but is typically negative for CD5 and CD10, although 10% to 20% of HCLs are positive for CD10.
A through C, The atypical lymphoid cells are positive for annexin A1 (partial) (A), DBA44 (B), and BCL1 (partial) (C) (original magnification X400 [A]; original magnification X200 [B]; original magnification X200 [C]).
667e +05 Annexin A1
(lipocortin 1); Lipocortin 1 (Homo sapiens) Accession Number: 4502101 Endoplasmic 28994-29033/6.
2]-Macroglobulin IPI00478003 639 Annexin A1
IPI00218918 297 Annexin A2 IPI00455315 116 Annexin A3 IPI00024095 85 Annexin A5 IPI00329801 268 Antithrombin III IPI00032179 18 Apolipoprotein A-I IPI00021841 593 Apolipoprotein E IPI00021842 51 Arginase 1 IPI00038356 43 [[beta].
1) 189 Heterogeneous nuclear ribonucleoprotein M 191 Annexin A1
(Lipocortin I) 192 Glutamyl-tRNA (GLn) amidotransferase subunit A 193 26S proteasome non-ATPase regulatory subunit 14 194 Isocitrate dehydrogenase (NAD) subunit, mitochondrial precursor 195 Cell division control protein 2 homolog (p34 protein kinase) 197 60S acidic ribosomal protein P0 198 26S Proteasome non-ATPase regulatory subunit 13 199 Actin alpha sarcomeric/cardiac 200 Actin, cytoplasmic 2 201 Tubulin beta 2 chain 202 Peroxiredoxin 4 205 Annexin A4 206 F-actin capping protein subunit beta isoforms 1 and 2 207 Chloride intracellular channel protein 4 208 Prohibitin 211 Proteasome subunit beta type 4 (EC 3.
Hairy cell leukemia expresses bright pan-B-cell antigens and, uniquely among B-cell neoplasms, strongly expresses CD11c, CD25, CD103, CD123, and annexin A1 typical ly.
However, HCL-v typically lacks expression of CD25, CD123, and annexin A1, which are all almost always expressed in classic HCL.
Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1).
Comparison of Immunophenotypic Findings in Splenic Small B-Cell Lymphomas (a) Variable CD5 CD10 CD11c CD25 CD103 CD123 IgM IgD SMZL -/+ - +/- -/+ -/+ - + +/- SDRPL -/+ - + - -/+ -/+ +/- +/- HCL-v - - + - + - -/+ -/+ HCL - -/+ + + + + + + LPL -/+ - + +/- - - + - Variable IgG Annexin A1 DBA.
In this study we investigated the in vitro effects of resveratrol on the apoptotic cascades in human promyelocyte leukemia (HL-60) cells and first demonstrated that growth arrest- and DNA damage-induced gene 45 [alpha] (GADD45 [alpha]) and annexin A1 are involved in the apoptosis effects of resveratrol in these cells.
Nitrocellulose membranes (Millipore, Bedford, MA, USA) were incubated overnight at 4[degrees]C with mouse annexin A1 monoclonal antibody or rabbit polyclonal antibodies against human Bcl-2, Bax, GADD45 [alpha] or cleaved caspase 3.
The protein expression of annexin A1 was increased with resver-atrol treatment (Fig.