ankyrin

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an·ky·rin

(ang'ki-rin),

An erythrocyte membranal protein that binds spectrin. A deficiency in ankyrin may lead to a type of hereditary spherocytosis.
See also: nexins.

Synonym(s): anchorin, syndein

[G. ankyra, anchor, + -in]

Farlex Partner Medical Dictionary © Farlex 2012

ankyrin

Any of a family of proteins which mediate the binding of integral membrane proteins to the cytoskeleton, e.g., spectrin to the erythrocyte’s anion exchange (band-III) protein.

ankyrin

(ang′kĭ-rin)

A structural protein in red blood cells that binds cell membrane transport molecules to spectrin.

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References in periodicals archive ?

Notch-regulated ankyrin repeat protein (NRARP) is a negative feedback regulator in Notch signaling pathway and regulated by Notch protein.[sup][8] On one hand, overexpression of Notch protein can promote NRARP expression; on the other hand, NRARP has feedback inhibition on the activity of Notch by inducing degradation of Notch receptor intracellular domain (NICD).[sup][9] In the present study, we found the overexpression of NRARP in thyroid cancer tissues and thyroid cancer cell lines (BHT101 and 8305C) and evaluated the effects of downregulation of NRARP expression on cell proliferation, cell cycle, invasion, and apoptosis.

Notch-regulated ankyrin repeat protein and Notch are highly expressed in thyroid cancer tissues

Downregulation of Notch-regulated ankyrin repeat protein expression significantly inhibits the proliferation of BHT101 and 8305C cells in vitro and in vivo

Downregulation of Notch-regulated ankyrin repeat protein expression induces G1 phase arrest in BHT101 and 8305C cells

Downregulation of Notch-regulated ankyrin repeat protein expression induces apoptosis in BHT101 and 8305C cells

Downregulation of Notch-regulated ankyrin repeat protein expression attenuates BHT101 and 8305C cell invasion

Downregulation of Notch-regulated Ankyrin Repeat Protein Exerts Antitumor Activities against Growth of Thyroid Cancer

The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous.

Ankyrin repeat domain-encoding genes in the wPip strain of Wolbachia from the Cuiex jipiens group.

Exploring symbioses by single-cell genomics

The six ankyrin repeats combined contain two nearly identical amino acid chains 223 amino acids long.