ankyrin repeat


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ankyrin repeat

A short repetitive sequence of amino acids consisting of a beta strand followed by two alpha helices and a beta strand. The beta strands on adjacent ankyrin repeats combine to form a short antiparallel beta sheet. Ankyrin repeats were first identified in ankyrin, which tethers different proteins (e.g., nuclear and cytoplasmic proteins), helping regulate gene expression and embryonic development.
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Background: The Notch-regulated ankyrin repeat protein (NRARP) is recently found to promote proliferation of breast cancer cells.
Downregulation of Notch-regulated Ankyrin Repeat Protein Exerts Antitumor Activities against Growth of Thyroid Cancer
The active ingredient, which comprises several DARPins (designed ankyrin repeat proteins), is also easy to produce.
Treatment to cure breast cancer for good gets closer
In a one-year re-integration phase I will perform follow-up mechanistic structural studies in the Olga Mayans lab (University of Liverpool) to determine the structural basis how the CARP (cardiac ankyrin repeat protein)-titin signaling axis mediates cardiomyocyte protection, and in the Labeit lab (University of Heidelberg, Medical Faculty Mannheim) how to perturb activity of this complex by small molecules.
Titin Signals: Molecular dissection of titin-based mechanisms in charge of cardiomyocyte loss in terminal heart failure
The Z-disk proteins include [alpha]-actinin 2, cardiac ankyrin repeat protein, muscle LIM protein, LIM binding domain 3, myozenin 2, telethonin, and vinculin/metavinculin.
Sudden Cardiac Death: A Modern Pathology Approach to Hypertrophic Cardiomyopathy
Source:RefSeq mRNA;Acc :NM_001109946] ENSSSCG00000005 607 RALGPS 1 Ral GEF with PH domain and SH3 binding motif 1 [Source:HGNC Symbol;Acc:16851] ENSSSCG00000005 679 ASB6 Sus scrofa ankyrin repeat and SOCS box containing 6 (ASB6), mRNA.
Genome-wide dna methylation profiles of small intestine and liver in fast-growing and slow-growing weaning piglets
Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat proteins provides access to novel HIV entry inhibitors," Journal of Virology 87(10): 5868-5881.
Recent publications
The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous.
Exploring symbioses by single-cell genomics
Biopharmaceutical company Cubist Pharmaceuticals Inc (NASDAQ:CBST) and Hydra Biosciences Inc announced on Tuesday the joint proposal to commence a Phase 1 clinical study for a small molecule antagonist of the human Transient Receptor Potential Ankyrin repeat 1 (TRPA1) ion channel.
Cubist Pharmaceuticals partners with Hydra Biosciences for Phase 1 clinical trial of TRPA1 Modulator for acute pain
Designed Ankyrin Repeat Proteins (DARPins): From research to therapy
Research and Markets: Protein Engineering for Therapeutics, Part A, Vol 502
Ankyrin repeat domain 30A (NY-BR-1) is another newly described marker useful in identifying a breast primary, although in limited publications.
Evolving Practices of Diagnostic Immunohistochemistry
today announced plans to begin a Phase 1 clinical trial for a small molecule antagonist of the human Transient Receptor Potential Ankyrin repeat 1 (TRPA1) ion channel discovered in a collaboration between Cubist and Hydra.
Cubist Pharmaceuticals and Hydra Biosciences Announce Plans to Begin Phase 1 Clinical Trial for Novel TRPA1 Modulator to Treat Acute Pain
ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene.
Clinical Data, Inc. Launches Genetic Test for Dilated Cardiomyopathy (DCM) at the 2009 American Heart Association Meeting

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