angiotensin II receptor antagonist

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angiotensin II receptor antagonist

Any of a family of agents (e.g., losartan and valsartan) that block the binding of angiotensin II (A-II) to their cognate cell receptors—AT1, AT2 and others. First-generation ARAs included the sartan family of agents, which only block AT1, interacting with the amino acids in the transmembrane domains to block the binding of A-II to AT1.

ARAs are an alternative to ACEI therapy in patients with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference of which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema.

angiotensin II receptor antagonist

Pharmacology Any of a family of agents-eg losartan and valsartan, which block the binding of angiotensin II–A-II to its cognate cell membrane receptors–AT1, AT2, and others; 1st generation ARAs included the sartan family of agents, which only block AT1, interacting with the amino acids in the transmembrane domains, blocking the binding of A-II to AT1; an alternative to ACEI therapy for Pts with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema.
References in periodicals archive ?
Lambert and her associates designed this pilot study because of previously reported results from other groups showing favorable effects of losartan on animal models of emphysema or other lung disease, as well as suggestions from nonprospective clinical studies of benefits from angiotensin-receptor blockers on lung function and on chronic obstructive pulmonary disease (COPD) in particular.
Angiotensin-receptor blockers and cancer: urgent regulatory review needed.
Unexpectedly, the angiotensin-receptor blocker had no effect on combined cardiovascular outcomes.
If these are problematic, you can switch to an angiotensin-receptor blocker (ARB).
Start patients on a half tablet daily of the lowest dose available for a fixed-dose combination of a diuretic plus either an angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker.
In these cases, an angiotensin-receptor blocker (ARB) may be substituted.
To start treatment according to the algorithm, which called for a low dose (half tablet) of a marketed formulation that combined a diuretic with either an angiotensin-converting enzyme inhibitor or an angiotensin-receptor blocker, physicians could choose among 11 formulations that were on the Canadian market at the time the study began.
Aliskiren failed to produce additional blood pressure lowering when it was added to an angiotensin-receptor blocker (valsartan).
Treatment of heart failure typically begins with an ACE inhibitor or an angiotensin-receptor blocker, mainly for historic reasons: ACE inhibitors were proven effective for treating heart failure first.
Until now, treatment of patients with heart failure usually began with an ACE inhibitor or an angiotensin-receptor blocker, primarily for historic reasons: ACE inhibitors were proven effective for treating heart failure first.
Most patients were also treated with an angiotensin-converting enzyme inhibitor or an angiotensin-receptor blocker, and most were also treated with a diuretic.
Most patients were also treated with an ACE inhibitor or an angiotensin-receptor blocker, and most were also treated with a diuretic.

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