ACE2

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ACE2

(1) Angiotensin-Converting Enzyme 2. An angiotensin-converting enzyme (ACE-like exopeptidase of the dipeptidyl carboxydipeptidase family) which is expressed predominantly in vascular endothelial cells of the heart, kidney and testes.
Physiology ACE2 appears to be a critical regulator of heart function and may counteract ACE activity.
(2) A gene on Xp22 which encodes a variant of angiotensin converting enzyme of the dipeptidyl carboxydipeptidase family, which is expressed on the vascular endothelial cells of the heart, kidneys and testes.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

ACE2

Angiotensin-converting enzyme 2 Therapeutics An ACE-like enzyme expressed in vascular endothelial cells of the heart and kidney Physiology ACE2 appears to be a critical regulator of heart function and may counteract ACE activity. See ACE.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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Vasilieva et al., "Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus," Nature, vol.
This includes the enzyme angiotensin-converting enzyme 2 (ACE2) which primarily forms Ang 1-7 from Ang II, but can also form Ang 1-9 from Ang I, prolylcarboxypeptidase which also forms Ang 1-7 from Ang II, and the enzymes neprilysin and prolylendopeptidase which forms Ang 1-7 directly from Ang I, and MAS, the putative receptor for Ang 1-7.
Antiglaucomatous effects of the activation of intrinsic Angiotensin-converting enzyme 2. Invest Ophthalmol Vis Sci 2013; 54: 4296-4306, doi: 10.1167/iovs.12-11427.
Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice.
Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension.
Lubel et al., "Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis," Journal of Hepatology, vol.
Chappell et al., "Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2," Circulation, vol.
T Cole-Jeffrey et al., "Diminazene aceturate enhances angiotensin-converting enzyme 2 activity and attenuates ischemia-induced cardiac pathophysiology," Hypertension, vol.
Ranganath, "Angiotensin-converting enzyme 2: enhancing the degradation of angiotensin II as a potential therapy for diabetic nephropathy," Kidney International, vol.
Ostrov, "Prediction of off-target effects on angiotensin-converting enzyme 2," Journal of Biomolecular Screening, vol.
To make the quail QT6/ACE2 cell line, the gene encoding the receptor for SARS-CoV, human angiotensin-converting enzyme 2 (ACE2) (35), was cloned from a human primary kidney cDNA library (Invitrogen, Paisley, Scotland, UK) using 21-mer primers designed to the start and stop of ACE2, and subcloned into pcdna3.1+.
The SARS-receptor molecule latched on to three proteins, but only one of these, angiotensin-converting enzyme 2 (ACE2), is typically found on the surface of mammalian cells.

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