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This includes the enzyme angiotensin-converting enzyme 2 (ACE2) which primarily forms Ang 1-7 from Ang II, but can also form Ang 1-9 from Ang I, prolylcarboxypeptidase which also forms Ang 1-7 from Ang II, and the enzymes neprilysin and prolylendopeptidase which forms Ang 1-7 directly from Ang I, and MAS, the putative receptor for Ang 1-7.
Antiglaucomatous effects of the activation of intrinsic Angiotensin-converting enzyme 2. Invest Ophthalmol Vis Sci 2013; 54: 4296-4306, doi: 10.1167/iovs.12-11427.
Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice.
Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension.
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To make the quail QT6/ACE2 cell line, the gene encoding the receptor for SARS-CoV, human angiotensin-converting enzyme 2
(ACE2) (35), was cloned from a human primary kidney cDNA library (Invitrogen, Paisley, Scotland, UK) using 21-mer primers designed to the start and stop of ACE2, and subcloned into pcdna3.1+.
The SARS-receptor molecule latched on to three proteins, but only one of these, angiotensin-converting enzyme 2
(ACE2), is typically found on the surface of mammalian cells.