angiotensin II receptor antagonist


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Related to angiotensin II receptor antagonist: ACE inhibitor, calcium channel blocker

angiotensin II receptor antagonist

Any of a family of agents (e.g., losartan and valsartan) that block the binding of angiotensin II (A-II) to their cognate cell receptors—AT1, AT2 and others. First-generation ARAs included the sartan family of agents, which only block AT1, interacting with the amino acids in the transmembrane domains to block the binding of A-II to AT1.

ARAs are an alternative to ACEI therapy in patients with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference of which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema.

angiotensin II receptor antagonist

Pharmacology Any of a family of agents-eg losartan and valsartan, which block the binding of angiotensin II–A-II to its cognate cell membrane receptors–AT1, AT2, and others; 1st generation ARAs included the sartan family of agents, which only block AT1, interacting with the amino acids in the transmembrane domains, blocking the binding of A-II to AT1; an alternative to ACEI therapy for Pts with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema.
References in periodicals archive ?
Kohlp, "Qsar approach insight the structural requirement of substituted quinazolinones derivatives as angiotensin ii receptor antagonists," Oxidation Communications, vol.
Comparative efficacy of two angiotensin II receptor antagonists, irbesartan and losartan in mild-to-moderate hypertension.
* There is need to test a potential additive effect of a low protein diet in combination with angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists or other antiproteinuric medications.
Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists for preventing the progression of diabetic kidney disease.
Other medications commonly used to treat hypertension include beta blockers such as atenolol (Tenormin), calcium channel blockers such as amlodipine (Norvasc), angiotensin II receptor antagonists such as losartan (Cozaar), and angiotensin-converting enzyme (ACE) inhibitors such as fosinopril (Monopril).

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