Preclinical data demonstrates that angiopoietins
act together with the VEGF family to promote the formation and maturation of blood and lymphatic vessels in the eye.
-like proteins (ANGPTLs), which are structurally similar to angiopoietins
, are characterized by a coiled-coil domain in the N-terminus and a fibrinogen-like domain in the C-terminus.
Vascular endothelial growth factor and angiopoietins
in neurovascular regeneration and protection following stroke.
are a family of vascular growth factors.
The role of the angiopoietins
in vascular morphogenesis.
Honda, "Expressions of angiopoietins
and Tie2 in human choroidal neovascular membranes," Investigative Ophthalmology and Visual Science, vol.
The lesions are polyclonal and have alterations in angiopoietins
, which may contribute to their vascular nature.
Changes in plasma vascular endothelial growth factor angiopoietins
and their receptors following surgery for breast cancer.
Expression of angiopoietins
and vascular endothelial growth factors and their clinical significance in acute myeloid leukemia.
Moreover, antiangiogenic drugs used in the clinic are centered on the blockade of the VEGF-signaling pathway, whereas VEGF-independent angiogenic factors such as fibroblast growth factor, angiopoietins
, placental growth factor (PlGF), matrix metalloproteases (MMPs), and ECM molecules are worth considering (6, 13).
Vessel cooption, regression, and growth in tumours mediated by angiopoietins
2], either directly, or biosynthesised following induction of COX-1 and COX-2 in HeLa cells, elevates the expression of potent pro- angiogenic factors such as basic fibroblast growth factor 2, vascular endothelial growth factor (VEGF) and angiopoietins