angiopoietin

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angiopoietin

(an″jē-ō-poy-ē′tĭn; -poy′ĕ-tĭn) [ angio- + -poiet(ic) + -in]
Any of several genes (or the proteins they encode) that stimulate new blood vessel formation. The proteins encoded by angiopoietin are found in healthy cardiac endothelium and in diseased tissues such as arthritic joints and malignant tumors.
References in periodicals archive ?
Preclinical data demonstrates that angiopoietins act together with the VEGF family to promote the formation and maturation of blood and lymphatic vessels in the eye.
Angiopoietin-like proteins (ANGPTLs), which are structurally similar to angiopoietins, are characterized by a coiled-coil domain in the N-terminus and a fibrinogen-like domain in the C-terminus.
Vascular endothelial growth factor and angiopoietins in neurovascular regeneration and protection following stroke.
Regeneron's angiopoietins are a family of vascular growth factors.
Honda, "Expressions of angiopoietins and Tie2 in human choroidal neovascular membranes," Investigative Ophthalmology and Visual Science, vol.
The lesions are polyclonal and have alterations in angiopoietins, which may contribute to their vascular nature.
Changes in plasma vascular endothelial growth factor angiopoietins and their receptors following surgery for breast cancer.
Moreover, antiangiogenic drugs used in the clinic are centered on the blockade of the VEGF-signaling pathway, whereas VEGF-independent angiogenic factors such as fibroblast growth factor, angiopoietins, placental growth factor (PlGF), matrix metalloproteases (MMPs), and ECM molecules are worth considering (6, 13).
Vessel cooption, regression, and growth in tumours mediated by angiopoietins and VEGF.
2], either directly, or biosynthesised following induction of COX-1 and COX-2 in HeLa cells, elevates the expression of potent pro- angiogenic factors such as basic fibroblast growth factor 2, vascular endothelial growth factor (VEGF) and angiopoietins.