ANGPTL4

(redirected from Angiopoietin-like protein 4)

ANGPTL4

A gene on chromosome 19p13.3 that encodes angiopoietin-like protein 4, which is expressed in endothelial cells in response to hypoxia. It is directly involved in regulating glucose homeostasis, lipid metabolism and insulin sensitivity; it may act as a regulator of angiogenesis and modulate tumourigenesis, and may protect endothelial cells by secreted factors. It reduces endothelial cell motility and inhibits sprouting and tube formation.
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References in periodicals archive ?
Another promising adipokine is angiopoietin-like protein 4 (ANGPTL4), a multifunctional signal protein expressed in many tissues.
Herrera, "Decreased concentrations of the lipoprotein lipase inhibitor angiopoietin-like protein 4 and increased serum triacylglycerol are associated with increased neonatal fat mass in pregnant women with gestational diabetes mellitus," The Journal of Clinical Endocrinology and Metabolism, vol.
Li, "Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4," Journal of Biological Chemistry, vol.
Basu et al., "Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity," The Journal of Biological Chemistry, vol.
Stienstra, "Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development," Arteriosclerosis Thrombosis Vascular Biology, vol.
Angiopoietin-like protein 4: health effects, modulating agents and structure-function relationships.
Tissue expression of angiopoietin-like protein 4 in cattle.
Machann et al., "Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-S and is of metabolic relevance in humans," Diabetes, vol.
Oiso, "Insulin downregulates angiopoietin-like protein 4 mRNA in 3T3-L1 adipocytes," Biochemical and Biophysical Research Communications, vol.
Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice.
Lam et al., "Overexpression of angiopoietin-like protein 4 alters mitochondria activities and modulates methionine metabolic cycle in the liver tissues of db/db diabetic mice," Molecular Endocrinology, vol.
Vanhoecke, "Angiopoietin-like protein 4: health effects, modulating agents and structure-function relationships," Expert Review of Proteomics, vol.