ANGPTL3

(redirected from Angiopoietin-like protein 3)

ANGPTL3

A gene on chromosome 1p31.1-p22.3 that encodes angiopoietin-like protein 3, which is expressed primarily in the liver.

Molecular pathology
ANGPTL3 mutations are associated with familial hypobetalipoproteinaemia type 2.
References in periodicals archive ?
Arrowhead Pharmaceuticals announced the presentation of new preclinical data on its expanding pipeline of RNA interference therapeutics for cardiometabolic diseases, including ARO-ANG3, which targets angiopoietin-like protein 3, and ARO-APOC3, which targets apolipoprotein C-III.
Arrowhead presents preclinical data on expanding cardiometabolic pipeline
Other medications belonging to the classes of antisense oligonucleotides are those that inhibit the production of the angiopoietin-like protein 3 (ANGPTL3) enzyme.
Novel approaches to lipid-lowering therapy
The product is an investigational monoclonal antibody to angiopoietin-like protein 3 (ANGPTL3).
The US FDA grants breakthrough therapy status to Regeneron Pharmaceuticals's evinacumab
Mabuchi et al., "Association of angiopoietin-like protein 3 with hepatic triglyceride lipase and lipoprotein lipase activities in human plasma," Annals of Clinical Biochemistry, vol.
Dietary Oxidized Linoleic Acid Modulates Plasma Lipids beyond Triglycerides Metabolism
Maranghi, "The angiopoietin-like protein 3: a hepatokine with expanding role in metabolism," Current Opinion in Lipidology, vol.
Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway
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