angiopoietin

(redirected from Angiopoietin-2)

angiopoietin

(an″jē-ō-poy-ē′tĭn; -poy′ĕ-tĭn) [ angio- + -poiet(ic) + -in]
Any of several genes (or the proteins they encode) that stimulate new blood vessel formation. The proteins encoded by angiopoietin are found in healthy cardiac endothelium and in diseased tissues such as arthritic joints and malignant tumors.
References in periodicals archive ?
AKB-9778 has demonstrated the ability to activate the Tie2 receptor irrespective of extracellular levels of its binding ligands, angiopoietin-1 (agonist) or angiopoietin-2 (antagonist).
RG7716 is the first bispecific, monoclonal antibody specifically designed for the eye that simultaneously binds to and inactivates vascular endothelial growth factor A and Angiopoietin-2.
In utero angiopoietin-2 gene delivery remodels placental blood vessel phenotype: a murine model for studying placental angiogenesis.
Angiopoietin-2 is increased in sepsis an inversely associated with nitric oxide-dependent microvascular reactivity.
2]-macroglobulin, glutathione S-transferase [alpha], peroxiredoxin-4, angiopoietin-2, macrophage derived chemokine, YKL-40, and insulin-like growth factor-binding protein 2 were all independently associated with mortality (55).
Background: Angiopoietin-2 (Ang-2) plays a crucial role in hypoxia-induced angiogenesis and is expressed only in sites of vascular remodeling.
Different growth factors, such as vascular endothelial growth factor (VEGF), Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2), have been identified as pro-angiogenic factors that are secreted by tumor cells to trigger normal endothelial cell (EC) growth through paracrine mechanisms via attachment to their corresponding receptors including vascular endothelial growth factor receptor-1, -2 (VEGFR-1,- 2) and Tie-2, respectively (Ciardiello et al.
Contract awarded for Angiopoietin-2 Immunoassay Kits and Immunoassay control, Human TGF-Beta 2 Immunoassay Kits and Control, Human GDF-11/BMP-11 MAb, Recombinanat Human GDF-11/BMP-11 and Reagent Diluent Conc 2 for testing of human plasma samples
The authors reported that Men-SCs were able to produce matrix metalloproteinase-3 (MMP3), MMP10, granulocyte macrophage colony-stimulating factor (GM-CSF), angiopoietin-2, and platelet-derived growth factor (PDGF)-BB in quantities 10 to 10,000 times higher than those in umbilical cord blood cells.
Stepwise increase of angiopoietin-2 serum levels is related to haemodynamic and functional impairment in stable chronic heart failure," European Journal of Cardiovascular Prevention & Rehabilitation, vol.
Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway.
2007) Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts.