AKB-9778 has demonstrated the ability to activate the Tie2 receptor irrespective of extracellular levels of its binding ligands, angiopoietin-1 (agonist) or angiopoietin-2
RG7716 is the first bispecific, monoclonal antibody specifically designed for the eye that simultaneously binds to and inactivates vascular endothelial growth factor A and Angiopoietin-2
In utero angiopoietin-2
gene delivery remodels placental blood vessel phenotype: a murine model for studying placental angiogenesis.
is increased in sepsis an inversely associated with nitric oxide-dependent microvascular reactivity.
2]-macroglobulin, glutathione S-transferase [alpha], peroxiredoxin-4, angiopoietin-2
, macrophage derived chemokine, YKL-40, and insulin-like growth factor-binding protein 2 were all independently associated with mortality (55).
(Ang-2) plays a crucial role in hypoxia-induced angiogenesis and is expressed only in sites of vascular remodeling.
Different growth factors, such as vascular endothelial growth factor (VEGF), Angiopoietin-1 (Ang-1) and Angiopoietin-2
(Ang-2), have been identified as pro-angiogenic factors that are secreted by tumor cells to trigger normal endothelial cell (EC) growth through paracrine mechanisms via attachment to their corresponding receptors including vascular endothelial growth factor receptor-1, -2 (VEGFR-1,- 2) and Tie-2, respectively (Ciardiello et al.
Contract awarded for Angiopoietin-2
Immunoassay Kits and Immunoassay control, Human TGF-Beta 2 Immunoassay Kits and Control, Human GDF-11/BMP-11 MAb, Recombinanat Human GDF-11/BMP-11 and Reagent Diluent Conc 2 for testing of human plasma samples
The authors reported that Men-SCs were able to produce matrix metalloproteinase-3 (MMP3), MMP10, granulocyte macrophage colony-stimulating factor (GM-CSF), angiopoietin-2
, and platelet-derived growth factor (PDGF)-BB in quantities 10 to 10,000 times higher than those in umbilical cord blood cells.
Stepwise increase of angiopoietin-2
serum levels is related to haemodynamic and functional impairment in stable chronic heart failure," European Journal of Cardiovascular Prevention & Rehabilitation, vol.
stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway.
2007) Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2