AKB-9778 has demonstrated the ability to activate the Tie2 receptor irrespective of extracellular levels of its binding ligands, angiopoietin-1
(agonist) or angiopoietin-2 (antagonist).
Blocking miR-34a or injecting angiopoietin-1
in the mouse models improved their lung architecture by up to 90 percent, compared to controls.
Several growth factors are closely associated with blood vessel formation and remodeling, such as angiopoietin-1
(Ang-1), angiopoietin-2 (Ang-2), and vascular endothelial growth factor (VEGF), [sup] each of which plays a different role in angiogenesis.
Conferone also precluded angiogenesis capability of treated HT-29 cells through an altered secretome profile, including vascular endothelial growth factor, Angiopoietin-1
and -2 factors.
, angiopoietin-2, and endostatin serum levels in inflammatory bowel disease," Inflammatory Bowel Diseases, vol.
Kim, "Tacrolimus (FK506) inhibits interleukin-1[beta]-induced angiopoietin-1
, Tie-2 receptor, and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes," Joint Bone Spine, vol.
Relationship between gingival angiopoietin-1
concentrations and depth of the adjacent gingival sulcus.
Although significant changes in angiopoietin-1
(ANGPT1) mRNA expression were not observed between each condition, mRNA expression tended to be elevated in Pre and Post in Hypo Tr.
2007) Sonic hedgehog inversely regulates the expression of angiopoietin-1
and angiopoietin-2 in fibroblasts.
High-level expression and purification of a designed angiopoietin-1
chimeric protein, COMP-Ang1, produced in Chinese hamster ovary cells.
74] suggested that angiopoietin-1
(Angl) may protect vascular endothelial cells from iopromide-induced apoptosis through PI 3-K and mTOR/S6 kinase, postulating that the pretreatment with Ang1 could help in maintaining normal vascular endothelial cell integrity before and during systemic RCM administration.
, angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring.