Effect of angiopoietin-1
on expression of Bcl-2 and Bax in human gastric cancer cells.
AKB-9778 activates the Tie2 receptor irrespective of extracellular levels of its binding ligands, angiopoietin-1
(agonist) or angiopoietin-2 (antagonist) and may be the most efficient pharmacologic approach to maintain normal Tie2 activation.
Our central hypothesis is that long-term gene delivery of COMP-Ang1 (angiopoietin-1
combined with the short coiled-coil domain of cartilage oligomeric matrix protein) has efficacy in promoting vascular normalization and neuroprotection in the presence of retinal ischemia.
Endothelial cells from visceral adipose tissue disrupt adipocyte functions in a 3D setting: Partial rescue by angiopoietin-1
. Diabetes 63, 535-549.
Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1
Koh, "Orchestral actions of angiopoietin-1
in vascular regeneration," Trends in Molecular Medicine, vol.
Multiple signaling and adhesion molecules are involved in vascular niche homeostasis, including Jag-1, Notch, c-kit, SCF, angiopoietin-1
(Ang-1), and Tie-2.
Katodritou et al., "Circulating angiopoietin-1
to angiopoietin-2 ratio is an independent prognostic factor for survival in newly diagnosed patients with multiple myeloma who received therapy with novel antimyeloma agents," International Journal of Cancer, vol.
The following factors prepared at 800 ng/mL were assayed and exhibited no cross-reactivity or interference: recombinant human angiopoietin-1
, angiopoietin-2, angiopoietin-4, and angiopoietin-like 3 and recombinant mouse angiopoietin-3 and angiopoietin-like 3.
It was also shown to secrete Angiopoietin-1
(Ang-1) in a time-dependent manner, which is downregulated in DR especially when grown in culture medium containing vascular growth factors was found to promote reendothelialization .
Hawkes et al., "Angiopoietin-1
and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis," Critical Care Medicine, vol.
Neutrophils promote tumor growth and metastasis by secreting vascular endothelial growth factor, angiopoietin-1
, and matrix metalloproteinase-9.