angiomotin


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angiomotin

A protein encoded by AMOT on Xq23 that mediates angiostatin inhibition of migration and tube formation of endothelial cells, and plays a central role in tight junction maintenance via the complex formed with ARHGAP17, regulating the uptake of polarity proteins at tight junctions. It may play a role in the assembly of endothelial cell–cell junctions.
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GenBank accession Protein Prey redundancy PBI number NM_205081 [beta]-Catenin 13 -DTDL XM_015280551 ADGRV1 (VLGR1) 4 -DTHL NM_204934 Gelsolin 2 -DVDV XM_004935864 TRIM35 1 -DVPV XM_015298217 CADM1 1 -EYFI XM_004940799 Angiomotin (AMOT) 1 -EYLI XM_416590 Golgin45 (BLZF1) 1 -LIAL XM_015286934 Numb 1 -EIEL XM_004945619 KCTD10 2 XM_015297094 CCDC27 2 XM_421324 TRIP11 (GMAP210) 1 Figure 7: Auditory brainstem response (ABR) measurements show normal auditory function of Cadm1 knockout mice.
helped define that Angiomotin is an alternative target of LATS1/2.
Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes cell proliferation and migration by upregulating angiomotin gene expression in human osteosarcoma cells.
VEGFR-2) Protein fragment cleaved from Angiomotin plasminogen which binds to and Angiostatin potentially many proteins to others ** induce its apoptosis.
Lu et al., "Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein," Genes and Development, vol.
reported that SNHG12 contributed to cell proliferation and migration by upregulating the expression of angiomotin in human osteosarcoma cells (12).