angiogenesis(redirected from Angiogenesis modulating agents)
Also found in: Dictionary, Thesaurus, Encyclopedia.
1. development of blood vessels in the embryo.
2. any formation of new blood vessels; see also neovascularization (def. 2) and revascularization. Called also angiopoiesis and vasculogenesis. adj., adj angiogenic.
tumor angiogenesis the induction of the growth of blood vessels from surrounding tissue into a tumor by a diffusible protein factor released by the tumor cells.
Development of new blood vessels.
[angio- + G. genesis, production]
n. pl. angiogene·ses (-sēz′)
The formation of new blood vessels.
an′gi·o·gen′ic (-jĕn′ĭk) adj.
angiogenesisThe development of new blood vessels from pre-existing vessels. Angiogenesis plays a fundamental role in embryonic development, tissue and wound repair, resolution of inflammation, and onset of neoplasia. It is linked to an array of pathological conditions (e.g., cancer, diabetic retinopathy, rheumatoid arthritis).
angiogenesisThe sprouting of new blood vessels and capillary beds from existing vessels, which plays a fundamental role in embryonic development, tissue and wound repair, resolution of inflammation, and onset of neoplasia; angiogenesis is linked to certain pathologies–eg, cancer, diabetic retinopathy, rheumatoid arthritis
1. Development of blood vessels in the embryo. 2. Any formation of new blood vessels.
[angio- + G. genesis, production]
angiogenesisThe origination and development of new capillary blood vessels in normal or malignant tissue. Angiogenesis is necessary so that a growing or enlarging tissue, with its increasing metabolic needs, obtains an adequate blood supply providing oxygen, nutrients and waste drainage. Various angiogenetic factors are secreted by blood-deprived (ischaemic) cells and these operate on the inner lining (endothelium) of existing blood vessels to cause the budding out of new capillaries. Angiogenesis can be exploited in two ways in medicine-it can, in theory be inhibited in the treatment of CANCER, DIABETIC RETINOPATHY, obesity, ENDOMETRIOSIS and ATHEROSCLEROSIS; or it can be encouraged to treat heart attacks, ununited fractures, neurodegenerative disease, peripheral blood circulation deficiencies and baldness.
angiogenesisprocess of forming new blood vessels, normally accompanies the growth of MALIGNANT tissue. TUMOURS need angiogenesis to provide the nutrients and oxygen for development and METASTATIS.
The formation of new blood vessels, for example, as a result of a tumor.
Mentioned in: Antiangiogenic Therapy
VEGF (vascular endothelial growth factor)
A major protein involved in regulating the differentiation and proliferation of vascular endothelial cells thus promoting the growth of new blood vessels (angiogenesis). VEGF is essential for normal embryonic development and contributes to the maintenance and repair of tissues. There are several VEGF proteins, depending on the number of amino acids that they contain (e.g. VEGF 121, VEGF 165, VEGF 189 and VEGF 206). However, under certain circumstances (e.g. higher than normal levels of VEGF as happens in hypoxia) it may participate in cancerous processes, inflammatory processes (e.g. rheumatoid arthritis) and ocular neovascularization as in exudative (wet) age-related macular degeneration and diabetic retinopathy. Anti-VEGF drugs are used to inhibit the action of VEGF. See anti-VEGF drugs.