angiogenesis inhibitor

(redirected from Angiogenesis inhibitors)
Also found in: Dictionary, Thesaurus.

inhibitor

 [in-hib´ĭ-tor]
1. any substance that interferes with a chemical reaction, growth, or other biologic activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.
ACE i's (angiotensin-converting enzyme i's) see angiotensin-converting enzyme inhibitors.
angiogenesis inhibitor a group of drugs that prevent growth of new blood vessels into a solid tumor.
aromatase i's a class of drugs that inhibit aromatase activity and thus block production of estrogens; used to treat breast cancer and endometriosis.
C1 inhibitor (C1 INH) a member of the serpin group, an inhibitor of C1, the initial component activated in the classical complement pathway. Deficiency of or defect in the protein causes hereditary angioedema.
carbonic anhydrase inhibitor an agent that inhibits the enzyme carbonic anhydrase; used in treatment of glaucoma and sometimes for epilepsy, familial periodic paralysis, acute mountain sickness, and kidney stones of uric acid.
cholinesterase inhibitor anticholinesterase.
COX-2 i's (cyclooxygenase-2 i's) a group of nonsteroidal antiinflammatory drugs that act by inhibiting cyclooxygenase-2 activity; they have fewer gastrointestinal side effects than other NSAIDs. Two members of the group are celecoxib and rofecoxib.
gastric acid pump inhibitor an agent that inhibits gastric acid secretion by blocking the action of H+,K+-ATPase at the secretory surface of gastric parietal cells; called also proton pump i.
HIV protease inhibitor any of a group of antiretroviral drugs active against the human immunodeficiency virus; they prevent protease-mediated cleavage of viral polyproteins, causing production of immature viral particles that are noninfective. Examples include indinavir sulfate, nelfinavir mesylate, ritonavir, and saquinavir.
HMG-CoA reductase i's a group of drugs that competitively inhibit the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, and are used to lower plasma lipoprotein levels in the treatment of hyperlipoproteinemia. Called also statins.
membrane inhibitor of reactive lysis (MIRL) protectin.
monoamine oxidase inhibitor any of a group of drugs that inhibit the action of monoamine oxidase, the enzyme that breaks down norepinephrine and serotonin, prescribed for their antidepressant action; the most widely used ones are isocarboxazid, phenelzine, and tranylcypromine. They are also used in the prevention of migraine.
α2-plasmin inhibitor α2-antiplasmin.
plasminogen activator inhibitor (PAI) any of several regulators of the fibrinolytic system that act by binding to and inhibiting free plasminogen activator. Their concentration in plasma is normally low, but is altered in some disturbances of bodily hemostasis. PAI-1 is an important fast-reacting inhibitor of t-plasminogen activator and u-plasminogen activator. Its synthesis, activity, and release are highly regulated; elevated levels of it have been described in a number of disease states. PAI-2 is a normally minor inhibitor that greatly increases in concentration during pregnancy and in certain disorders. PAI-3 is protein C inhibitor.
platelet inhibitor any of a group of agents that inhibit the clotting activity of platelets; the most common ones are aspirin and dipyridamole. See also antiplatelet therapy.
protease inhibitor
1. a substance that blocks activity of endopeptidase (protease), such as in a virus.
protein C inhibitor the primary inhibitor of activated anticoagulant protein C; it is a glycoprotein of the serpin family of proteinase inhibitors and also inhibits several other proteins involved in coagulation (thrombin, kallikrein, and coagulation factors X and XI) and urokinase. Called also plasminogen activator inhibitor 3.
proton pump inhibitor gastric acid pump i.
reverse transcriptase inhibitor a substance that blocks activity of the reverse transcriptase of a retrovirus and is used as an antiretroviral agent. Some are nucleosides or nucleoside analogues, and those that are not are therefore often called non-nucleoside reverse transcriptase inhibitors.
selective serotonin reuptake inhibitor (SSRI) any of a group of drugs that inhibit the inactivation of serotonin by blocking its absorption in the central nervous system; used as antidepressants and in the treatment of obsessive-compulsive disorder and panic disorder.
serine protease inhibitor (serine proteinase inhibitor) serpin.
topoisomerase i's a class of antineoplastic agents that interfere with the arrangement of DNA in cells.

angiogenesis inhibitor

n.
A drug that blocks angiogenesis in cancerous tissue, thus interfering with tumor growth or metastasis.

angiogenesis inhibitor

A chemotherapy adjuvant (e.g., TNP-470, Avastin) that inhibits the angiogenesis required for tumour growth and survival, especially for metastastatic tumours.

angiogenesis inhibitor

Oncology A chemotherapy adjuvant which inhibits the angiogenesis required for tumor growth and survive, especially for metastastatic tumors See CAI, CM101, IFN-alpha, IL-12, Marimastat, Pentosan polysulfate, Platelet factor 4, Thalidomide, TNP-470.

angiogenesis inhibitor

One of a range of substances that block the development of new blood vessels (angiogenesis) and show promise as anticancer drugs. Cancers cannot grow beyond microscopic size unless they develop new blood vessels. If this is prevented they will regress or remain dormant and harmless. Research has shown that the angiogenesis inhibitors endostatin and angiostatin are capable of eliminating cancers of the breast, colon, prostate and brain in mice and can do so without undesirable side effects in the short term. These two drugs act in different ways and research on humans with cancer was started in mid-1998. The drugs are believed not to induce drug resistance in mice.
References in periodicals archive ?
Angiogenesis inhibitors: Just as angiogenesis inhibitors decrease blood-vessel growth that feeds cancer cells, a protocol that stems new foreign fighters and military equipment, financial and commercial transactions that nourish ISIS tumors has proven feasible but not a game-changer.
The clinical efficacy of angiogenesis inhibitors has recently been met with numerous phase III failures that showed modest survival benefits because tumors elicit evasive resistance [151].
In this report, we determined the antitumor and antiangiogenesis activities of lenvatinib, an angiogenesis inhibitor that targets multiple RTKs, in 11 human thyroid cancer xenograft models with 3 types of histology (DTC, MTC, and ATC).
However, angiogenesis inhibitors inhibit the growth of blood vessels rather than tumor cells.
"Those papers really helped things get started, and helped pave the way to angiogenesis inhibitors," says Langer.
angiogenesis inhibitors in lung cancer, vaccine therapy, small cell carcinoma of the lung, mesothelioma, statistical and study design methodologies in clinical oncology research, palliative care for patients with lung cancer, and the future of lung cancer.
Unfortunately, many existing angiogenesis inhibitors have toxic side effects, prompting scientists to seek safer, natural alternatives.
Owing to the encouraging results obtained to date by many studies, angiogenesis inhibitors have been approved by the FDA as a treatment for cancer.
Study sheds light on angiogenesis inhibitors, points to limitations, solutions [press release].
Drugs called angiogenesis inhibitors prevent the growth of blood vessels that supply tumours with oxygen and nutrients.
Further research is needed to determine which markers will help us to predict the activity of cetuximab and panitumumab in addition to KRAS status and also to find predictive markers for angiogenesis inhibitors.
The rationale behind AE-941 starts with cartilage being an avascular tissue known to contain angiogenesis inhibitors. Because cartilage comprises 6%-8% of a shark's body weight, proponents have argued that sharks could be a good source for cartilage from which to make an antitumor drug.