angiogenesis

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angiogenesis

 [an″je-o-jen´ĕ-sis]
1. development of blood vessels in the embryo.
2. any formation of new blood vessels; see also neovascularization (def. 2) and revascularization. Called also angiopoiesis and vasculogenesis. adj., adj angiogenic.
tumor angiogenesis the induction of the growth of blood vessels from surrounding tissue into a tumor by a diffusible protein factor released by the tumor cells.

an·gi·o·gen·e·sis

(an'jē-ō-jen'ĕ-sis),
Development of new blood vessels.
Synonym(s): arteriogenesis
[angio- + G. genesis, production]

angiogenesis

(ăn′jē-ō-jĕn′ĭ-sĭs)
n. pl. angiogene·ses (-sēz′)
The formation of new blood vessels.

an′gi·o·gen′ic (-jĕn′ĭk) adj.

angiogenesis

The development of new blood vessels from pre-existing vessels. Angiogenesis plays a fundamental role in embryonic development, tissue and wound repair, resolution of inflammation, and onset of neoplasia. It is linked to an array of pathological conditions (e.g., cancer, diabetic retinopathy, rheumatoid arthritis).

angiogenesis

The sprouting of new blood vessels and capillary beds from existing vessels, which plays a fundamental role in embryonic development, tissue and wound repair, resolution of inflammation, and onset of neoplasia; angiogenesis is linked to certain pathologies–eg, cancer, diabetic retinopathy, rheumatoid arthritis

an·gi·o·gen·e·sis

(an'jē-ō-jen'ĕ-sis)
1. Development of blood vessels in the embryo. 2. Any formation of new blood vessels.
[angio- + G. genesis, production]

angiogenesis

The origination and development of new capillary blood vessels in normal or malignant tissue. Angiogenesis is necessary so that a growing or enlarging tissue, with its increasing metabolic needs, obtains an adequate blood supply providing oxygen, nutrients and waste drainage. Various angiogenetic factors are secreted by blood-deprived (ischaemic) cells and these operate on the inner lining (endothelium) of existing blood vessels to cause the budding out of new capillaries. Angiogenesis can be exploited in two ways in medicine-it can, in theory be inhibited in the treatment of CANCER, DIABETIC RETINOPATHY, obesity, ENDOMETRIOSIS and ATHEROSCLEROSIS; or it can be encouraged to treat heart attacks, ununited fractures, neurodegenerative disease, peripheral blood circulation deficiencies and baldness.

angiogenesis

process of forming new blood vessels, normally accompanies the growth of MALIGNANT tissue. TUMOURS need angiogenesis to provide the nutrients and oxygen for development and METASTATIS.

Angiogenesis

The formation of new blood vessels, for example, as a result of a tumor.

VEGF (vascular endothelial growth factor) 

A major protein involved in regulating the differentiation and proliferation of vascular endothelial cells thus promoting the growth of new blood vessels (angiogenesis). VEGF is essential for normal embryonic development and contributes to the maintenance and repair of tissues. There are several VEGF proteins, depending on the number of amino acids that they contain (e.g. VEGF 121, VEGF 165, VEGF 189 and VEGF 206). However, under certain circumstances (e.g. higher than normal levels of VEGF as happens in hypoxia) it may participate in cancerous processes, inflammatory processes (e.g. rheumatoid arthritis) and ocular neovascularization as in exudative (wet) age-related macular degeneration and diabetic retinopathy. Anti-VEGF drugs are used to inhibit the action of VEGF. See anti-VEGF drugs.
References in periodicals archive ?
Akhtar, "Angiogenesis assays: a critical overview," Clinical Chemistry, vol.
Progressively, it is visible that there is an increasing use of in vitro angiogenesis assays, with a peak in 2016.
Another ex vivo murine retina angiogenesis assay is described by Rezzola and colleagues [4].
It is a well-known fact that cells in vitro both gain and lose attributes found in vivo, and it is generally not feasible to use truly primary (not passaged) endothelial cells in angiogenesis assays.
In contrast to the mouse corneal angiogenesis assay, which requires considerable technical skill, the Matrigel plug assay is not difficult to administer (41).
The sponge Matrigel angiogenesis assay. Angiogenesis 2002;5:in press.
ND-EC were cultured under conditions designed to mimic the in vivo environment of T2DM and the impact on angiogenesis assays was evaluated.