angiopoietin

(redirected from Ang-2)

angiopoietin

(an″jē-ō-poy-ē′tĭn; -poy′ĕ-tĭn) [ angio- + -poiet(ic) + -in]
Any of several genes (or the proteins they encode) that stimulate new blood vessel formation. The proteins encoded by angiopoietin are found in healthy cardiac endothelium and in diseased tissues such as arthritic joints and malignant tumors.
References in periodicals archive ?
Ang-2 expression can be regulated by hypoxia inducible factors and other regulators with exposure to hypoxia.
Ang-1 promotes vascular stabilization and counteracts VEGF-induced angiogenesis whereas Ang-2 promotes angiogenesis by reducing the destabilization of endothelial cell junctions to enhance new vessel branching and sprouting.
sup][11] Ang-2 plays a crucial role in this hypoxia-induced angiogenesis, and increased levels of Ang-2 concentrations can be detected in the peripheral blood of patients with CHD.
Given this information, we hypothesized that serum Ang-2 concentrations in patients with CHD might decrease after myocardial blood reperfusion by percutaneous coronary intervention (PCI) and the greater decreases in Ang-2 after PCI accompany more severe coronary artery stenosis.
Ang-2 concentrations in the blood samples were measured using enzyme-linked immunosorbent assay kits according to the manufacturer's instructions (RayBiotech, Inc.
Pre-PCI serum Ang-2 concentrations in the study group were significantly higher than those in the control group (4625.
Materials and Methods: Ang-2 and Tie-2 were measured in plasma samples from AML patients and controls using enzyme-linked immunosorbent assay (ELISA).
Yontem ve Gerecler: AMLli hastalar ve kontorllerden alinan plazma orneklerinde, Enzim bagli immunassay (ELISA) ile Ang-2 ve Tie -2 olculmustur.
sonuc: Calismada elde edilen sonuclarda, AML hastalarinin dolasimdaki Ang-2 ve sTie-2 duzeylerinin prognostik anlamliligi gosterilmistir.
Ang-1 and its naturally occurring antagonist Ang-2 act via the Tie-2 receptor tyrosine kinase, which is broadly expressed in the endothelium of the adult vasculature and in a subset of hematopoietic stem cells.
Plasma levels of Ang-2 and Tie-2 were assayed by enzyme-linked immunosorbent assay (ELISA) using commercially available kits (Quantikine, R&D systems) according to the manufacturer*s instructions.
Medians, means and ranges of plasma levels of Ang-2 and Tie-2 in AML patients and healthy controls are presented in Table 2.