anemia of chronic disease


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Related to anemia of chronic disease: iron deficiency anemia, hemolytic anemia

anemia of chronic disease

Hematology A form of anemia that accounts for14 of all anemias in hospitalized Pts; it is the predominant form of hypoproliferative anemia, and seen in Pts with arthritis, chronic infections, and malignancy, which interferes with RBC production and shortens RBC lifespan Clinical Findings reflect the underlying disease Lab Mild-to-moderate anemia, often microcytic ± hypochromic; iron stores may be low/normal; RBC indices may be normal Pathogenesis Unknown; ? related to IFN-γ produced by activated macrophages Treatment Transfusion, erythropoietin.
References in periodicals archive ?
Anemia of chronic disease (ACD), also referred to as anemia of inflammation, is clearly responsible for many cases of anemia observed in the elderly.
Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: Improvement following anti-tumor necrosis factor-alpha antibody therapy.
Baseline demographics and disease characteristics Variable Value n % Mean[+ or -]SD Age, years 37.3[+ or -]7.9 Sex Male 35 81.4 Female 8 18.6 Disease duration (years) 5.14[+ or -]3.4 HLA-B27 positivity 37 86.0 Drugs before anti-TNF therapy NSAIDs 1 2.3 NSAIDs + sulfasalazine 9 20.9 NSAIDs + sulfasalazine + methotrexate 33 76.7 Duration of DMARD treatment before anti-TNF therapy (months) 31.9[+ or -]20.0 Anemia 12 27.9 Anemia of chronic disease 4 9.3 Iron deficiency anemia 8 18.6 Anti-TNF inhibitors Etanercept 26 60.4 Infliximab 14 32.6 Adalimumab 3 7.0 HLA: Human leukocyte antigen; NSAIDs: Non-steroidal anti-inflammatory drugs; DMARDs: Disease-modifying anti-rheumatic drugs; TNF: Tumor necrosis factor-alpha; Values are expressed as mean [+ or -] standard deviation unless otherwise stated.
This increased synthesis leads to a deficiency of iron available for erythropoiesis, and is considered to be the mechanism underlying reticuloendothelial (RE) iron sequestration, intestinal iron absorption impairment, and low serum iron concentrations characteristic of anemia of chronic disease.
Advances in the anemia of chronic disease. Int J Hematol 1999; 70: 7-12.
Several diseases result in normocytic anemia, including aplastic anemia, acute blood loss, hemolytic anemia, and anemia of chronic disease (Gaspad, 2005; Young, Calado, & Scheinberg, 2006).
We'll never get questions about anemia of chronic disease or uncontrolled hypertension or diabetes.
A test for iron, total iron-binding capacity, percentage saturation of iron-binding capacity, ferritin and soluble transferrin receptor levels will distinguish anemia of chronic disease (ACD) from iron-deficiency anemia (IDA).
The diseased control group consisted of patients with rheumatoid arthritis and anemia of chronic disease.
Anemia of chronic disease. New England Journal of Medicine, 5, 352, 1011-1023.
Is Obesity Associated With Anemia of Chronic Disease? A Population-based Study: Obesity 2008; 16: 2356-2361.
In contrast, in anemia of chronic disease and anemia of cancer, data suggest that hepcidin concentrations are increased, causing decreased absorption of iron and increased sequestration of iron in the reticulo-endothelial system, which together account for the observed anemia (6, 14-18).