Androgens


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androgens

Male sex hormones. Androgens are STEROIDS and include testosterone and androsterone. As drugs, they are used to stimulate the development of sexual characteristics in boys when there is inadequate output from the testicles and to stimulate red cell formation in APLASTIC ANAEMIA. See also ANABOLIC STEROIDS. The term androgen derives from the Greek andros , a man and gennao , to make.

Androgens

Male sex hormones produced by the adrenal glands and testes, the male sex glands.
References in periodicals archive ?
Androgen reporter assays can easily detect EDCs that alter androgen signaling by mimicking androgens or by blocking the classical androgen receptor transcription pathway.
Another interesting aspect in our patient's case was her moderate response to anti-androgens (flutamide), which may suggest the existence of an active androgen receptor (AR) pathway.
The principal androgens are testosterone and androstenedione.
We present a cross-sectional cohort study of the expression of HER-2 and MMP-2 in bone marrow micrometastasis detected in bone marrow biopsies and compare the effect of androgen blockade on HER-2 and MMP-2 expressions in tumor and surrounding stromal cells with that of men without androgen blockade.
High androgen levels, fatty meals, red meat consumption, minimum exercise and obesity are also other risk factors being reported, but their role in development of disease is controversial.5 Most of the prostatic carcinoma patients do not present any symptoms during its initial stages.
Testosterone (T) and dihydrotestosterone (DHT) are synthesized in the skin and bind to the androgen receptor.4 Clinical studies support the role of androgenic hormones in acne pathogenesis and cite the approximation of acne onset with surge of dihydroepiandrosterone sulphate (DHEA-S), acne in congenital adrenal hyperplasia (CAH), sudden onset acne, androgens administration leading to acne and improvement by androgen receptor blockers.
The dominant effect of androgens on oestrogen-related tumours is antiproliferative and a decrease in AR-mediated effects might favour tumorigenesis.
Although AR or high levels of circulating plasma androgens have been documented in females in a wide array of taxa (Iela et al., 1986; Yalcinkaya et al., 1993; Yoshimura et al., 1993), the molecular mechanism of androgen action and the role of AR in the female birds reproductive tract have not yet been demonstrated.
Hyperthecosis is a condition where ovarian stroma possesses nests of luteinized theca cells that produce large amounts of androgens [10].
Hyperandrogenism is considered to be one of the most important factors [8], and increased androgen concentration in the follicular fluid is associated with elevated serum levels of luteinizing hormone that can arrest follicle development and lead to follicular degeneration [9].
We all have androgens in our bodies, although men have 10 times more than women.