'This is noteworthy because it's been so long since there has been a new, first-in-class molecule for the treatment of acne, particularly given that it is a topical treatment that targets the androgen receptor
and works on sebocytes to mediate lipid production and inflammation,' said Dr.
(AR)" is a 110 KD nuclear receptor located on Xq11-12.
Genetic association between androgen receptor
gene CAG repeat length polymorphism and male infertility: a meta-analysis.
Novel (60%) and recurrent (40%) androgen receptor
gene mutations in a series of 59 patients with a 46,XY disorder of sex development.
(AR) malfunction is associated with acne.5 Patients with androgen excess, like Cushing's syndrome, Polycystic Ovaries (PCOs) and CAH, can all have acne.
Through the immunohistochemistry method using Dako reagents, the presence of Androgen receptor
in the above group of 72 patients were studied.
expression in clinically localized prostate cancer: immunohistochemistry study and literature review.
Hen, Androgen receptor
, Oviduct, qPCR, Immunohistochemistry.
The researchers used a technique known as RNA interference to inhibit androgen receptor
activity in the cultured cells and then exposed the cells to KSHV.
In the primary trial of 171 patients, men found to have multiple copies of the androgen receptor
gene were four times more likely to die than those who had a negative test result.
Tindall, "Androgen receptor
signaling in prostate cancer development and progression," Journal of Carcinogenesis, vol.
Testosterone, along with its metabolite dihydrotestosterone, exerts its effects by binding to the androgen receptor