androgen insensitivity syndrome

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Related to Androgen insensitivity: Partial androgen insensitivity syndrome

androgen

 [an´dro-jen]
any steroid hormone that promotes male secondary sex characters. The two main androgens are androsterone and testosterone. Called also androgenic hormone. adj., adj androgen´ic. 

The androgenic hormones are internal endocrine secretions circulating in the bloodstream and manufactured mainly by the testes under stimulation from the pituitary gland. To a lesser extent, androgens are produced by the adrenal glands in both sexes, as well as by the ovaries in women. Thus women normally have a small percentage of male hormones, in the same way that men's bodies contain some female sex hormones, the estrogens. Male secondary sex characters include growth of the beard and deepening of the voice at puberty. Androgens also stimulate the growth of muscle and bones throughout the body and thus account in part for the greater strength and size of men as compared to women.
androgen insensitivity syndrome complete androgen resistance.

an·dro·gen re·sis·tance syn·dromes

a class of disorders associated with 5α-steroid reductase deficiency, testicular feminization, and related disorders. Compare: steroid 5α-reductase, Reifenstein syndrome, infertile male syndrome, testicular feminization syndrome.

androgen insensitivity syndrome

n.
An inherited condition in which the body cells are completely or partially unable to respond to androgens, resulting, in the complete form, in a person with an XY karyotype developing typical female external genitalia but usually no uterus, a short vagina, and undescended or partially descended testes. People with mild or partial forms are infertile and have a variety of phenotypes.

an·dro·gen re·sis·tance syn·dromes

(an'drŏ-jen rĕ-zis'tăns sin'drōmz)
A class of disorders associated with 5α-steroid reductase deficiency, testicular feminization, and related disorders.
Compare: Reifenstein syndrome, testicular feminization syndrome
Synonym(s): androgen insensitivity syndrome.
References in periodicals archive ?
Mutations of androgen receptor gene in androgen insensitivity syndromes.
ISNA News, redesigned and rejuvenated this month after a move from its beginnings in San Francisco to a new home in Michigan, is published by the Intersex Society of North America, whose board of directors includes representatives of the Androgen Insensitivity Support Group, the International Gay and Lesbian Human Rights Commission, the Intersex Society, and the Michigan State University Dept.
Weir examines the various theories as to the reasons for her revulsion, from feminine independence to fear of childbirth - even the suggestion that she was alike with the Duchess of Windsor in being the victim of a condition known as Androgen Insensitivity Syndrome, under which sufferers are born with male XY chromosomes but develop outwardly as females, albeit lacking the physical capacity for pregnancy.
A small sampling of topics: thyroid hormone transporters and resistance, clinical and molecular aspects of androgen insensitivity, pseudohypoaldosteronism, current issues on molecular diagnosis of GH signaling defects, and human congenital perilipin deficiency and insulin resistance.

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