An ABc mutant NMDAR would be expected to mimic overexpression of GluN2A at immature synapses, due to the non-specificity of the predominating PSD anchoring protein, SAP102, for GluN2A or G1uN2B.
Due to postnatal modifications in the types of anchoring proteins that occupy the PSD, this slot and peg phenomenon has important ramifications for developmental regulation of synaptic NMDAR composition as well as proteomic analysis of NMDAR molecular complexes (Husi et at.
Epidermolysis Bullosa (EB) is a heterogeneous group of diseases characterized by a genetic defect of the anchoring proteins
between the epidermis and the dermis and can be inherited either autosomal recessively or autosomal dominant.
There is mounting evidence that regulation of actinmembrane anchoring by lipids and dedicated anchoring proteins
is critical for the formation of dynamic actin structures needed for essential functions such as cell division, migration, and mechanosensing.