The developmental GluN2B-to-GluN2A subunit switch alters a number of NMDAR properties including affinity for glutamate, small molecules (phenylethanolamines, PEAs), and ions (protons, zinc); channel open probability and deactivation rates; the presence or absence of activity-dependent synaptic integration; and subunit-selective interactions with intracellular signaling and anchoring proteins
Epidermolysis Bullosa (EB) is a heterogeneous group of diseases characterized by a genetic defect of the anchoring proteins
between the epidermis and the dermis and can be inherited either autosomal recessively or autosomal dominant.
Schneewind, "Sortases and the art of anchoring proteins
to the envelopes of gram-positive bacteria," Microbiology and Molecular Biology Reviews, vol.
In this project we aim to investigate the effect of mechanical forces in the anchoring proteins
and its role during attachment.
There is mounting evidence that regulation of actinmembrane anchoring by lipids and dedicated anchoring proteins
is critical for the formation of dynamic actin structures needed for essential functions such as cell division, migration, and mechanosensing.