anaplastic lymphoma kinase


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anaplastic lymphoma kinase

A member of the insulin receptor subfamily of receptor tyrosine kinases, which acquires transforming capability when truncated and fused to nucleophosmin in the t(2;5) chromosomal rearrangement, resulting in the NPM-ALK chimeric protein associated with NHL.

Normal expression
Small intestine, testis, brain.
References in periodicals archive ?
Abbreviations: ALK, anaplastic lymphoma kinase; EGFR, epidermal growth factor receptor.
Deng, "Inflammatory myofibroblastic tumour of the testis with confirmed anaplastic lymphoma kinase gene rearrangement," Histopathology, vol.
Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma.
Two additional subtypes of DLBCL, ALK (anaplastic lymphoma kinase) positive DLBCL and primary effusion lymphoma, also have plasmablastic features and do not express CD 20 [15,16].
The emerging pathogenic and therapeutic importance of anaplastic lymphoma kinase. Eur J Cancer 2010; 46: 2357-68.
Two pathologic subtypes of systemic ALCL are recognized according to the presence of a translocation involving the Anaplastic Lymphoma Kinase gene known as ALK.
Mutations of a gene called anaplastic lymphoma kinase (ALK) are behind most incidences of hereditary neuroblastoma, a rare and deadly childhood cancer, as well as high-risk noninherited forms of the disease, a new study suggests.
Announced that the European Commission (EC) granted conditional marketing authorization for LORVIQUA (lorlatinib, available in the U.S., Canada and Japan under the brand name LORBRENA), as a monotherapy for the treatment of adult patients with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC) whose disease has progressed after alectinib or ceritinib as the first ALK tyrosine kinase inhibitor (TKI) therapy, or crizotinib and at least one other ALK TKI.
(19) Epithelial membrane antigen-positive anaplastic large cell lymphoma are usually CD30- and anaplastic lymphoma kinase-positive and show the classic anaplastic lymphoma kinase translocation t(2;5)(p23;q35) in 80% of cases.
United States-based Pfizer has received recommendation from The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) for its Lorviqua (lorlatinib) intended to treat adult patients with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC), it was reported yesterday.
Buller, Vice President of Oncology, Clinical Development & Head of Global Product Development at Pfizer will give a keynote presentation on, "Feedback Loops Between Biomarkers and Targeted Agents in Clinical Trials and Beyond: Lessons from Anaplastic Lymphoma Kinase (ALK+) Driven Non-Small Cell Lung Cancer (NSCLC)" at GTCbio's Biomarker Summit Europe 2016 to be held on October 5-7, 2016 in Berlin, Germany.
Immunohistochemical staining was positive for anaplastic lymphoma kinase (ALK), consistent with the diagnosis of IMT (Figure 2(b)).