anaphase promoting complex

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anaphase promoting complex

A large protein complex of 11 to 13 proteins—including cullin (Apc2), RING (Apc11), and other proteins of as yet unknown functions—which is an E3 ubiquitin ligase that targets cell cycle proteins for degradation by the 26S proteasome.
References in periodicals archive ?
Solomon, "The anaphase-promoting complex: it's not just for mitosis any more," Genes & Development, vol.
Peters, "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons," Proceedings of the National Academy of Sciences of the United States of America, vol.
Kaplan, "The anaphase-promoting complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C.
Objective: This research proposal describes an ambitious effort to characterize structurally and biochemically ubiquitin chain initiation and elongation by the anaphase-promoting complex or cyclosome (APC/C) in complex with two well-characterized substrates.
elegans, multiple ubiquitin ligases have been implicated in UPS-dependent regulation of AMPAR synaptic abundance, including the anaphase-promoting complex (APC) [48], CUL3/KEL-8 [49], and RPM-1 [50].
This work has revealed detailed properties of key regulatory proteins, including the cyclin-dependent protein kinases and an ubiquitin ligase known as the Anaphase-Promoting Complex. His signature contributions include the discovery of numerous regulators and targets of these enzymes.