anaphase promoting complex

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anaphase promoting complex

A large protein complex of 11 to 13 proteins—including cullin (Apc2), RING (Apc11), and other proteins of as yet unknown functions—which is an E3 ubiquitin ligase that targets cell cycle proteins for degradation by the 26S proteasome.
References in periodicals archive ?
The second article details a high throughput screening process that Rigel has developed to screen the anaphase-promoting complex (APC), an E3 ubiquitin ligase under scrutiny as an anti-cancer target.
A team from The Institute of Cancer Research, London, and the Medical Research Council Laboratory of Molecular Biology in Cambridge produced the first detailed images of the anaphase-promoting complex (APC/C).