anal intraepithelial neoplasia


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anal intraepithelial neoplasia

A carcinoma in situ of the anorectal mucosa that is embryologically, histologically, and pathologically analogous to cervical intraepithelial neoplasia, which is linked to HPV infection and divided into low-grade (LG-AIN) and high-grade (HG-AIN) tumours, the latter of which is associated with aggressive squamous cell carcinoma.

Risk factors
Anal HPV infections, receptive anal intercourse, HIV infection and decreased CD4-+ve T cells.
 
HPV types
6/11, 31/33/35 and 16/18.

anal intraepithelial neoplasia

Abbreviation: AIN
A precancerous change in the squamous cells of the anus that may eventually develop into anorectal cancer. It is similar to cervical intraepithelial neoplasia in that it is a premalignant lesion that arises in squamous cells, is found primarily in sexually active people, and is associated with human papillomavirus and HIV.
Synonym: anal dysplasia; anal squamous intraepithelial lesion
See also: neoplasia
References in periodicals archive ?
Efficacy of trichloroacetic acid in the treatment of anal intraepithelial neoplasia in HIV-positive and HIV-negative men who have sex with men.
Summary of studies focused on effectiveness of different treatment modalities of anal intraepithelial neoplasia (AIN).
High resolution anoscopy findings for men who have sex with men: inaccuracy of anal cytology as a predictor of histologic high-grade anal intraepithelial neoplasia and the impact of HIV serostatus.
Self-collected versus clinician-collected anal cytology specimens to diagnose anal intraepithelial neoplasia in HIV-positive men.
The vaccine was 73% efficacious against anal intraepithelial neoplasia of grade 1, including condyloma, and 74.
In the intention-to-treat population, vaccine efficacy against anal intraepithelial neoplasia related to any of the four HPV types was 50.
HRA sensitivity in detecting anal intraepithelial neoplasia among different high-risk populations has been demonstrated to be about 69 to 93%, with a specificity ranging from 32 to 64%.
High-grade anal intraepithelial neoplasia among HIV-1-infected men screening for a multicenter clinical trial of a human papillomavirus vaccine.
Conventionally, lesions involving the former have been termed dysplasia, in situ carcinoma, or anal intraepithelial neoplasia, whereas lesions involving the skin, Bowen disease.
Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection.
GARDASIL is not intended to be used for treatment of active external genital lesions; cervical, vulvar, vaginal, and anal cancers; cervical intraepithelial neoplasia, vulvar intraepithelial neoplasia, vaginal intraepithelial neoplasia, or anal intraepithelial neoplasia.
Food and Drug Administration (FDA) has approved GARDASIL([R]) [Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant] for the prevention of anal cancer caused by human papillomavirus (HPV) types 16 and 18 and for the prevention of anal intraepithelial neoplasia (AIN) grades 1, 2 and 3 (anal dysplasias and precancerous lesions) caused by HPV types 6, 11, 16 and 18, in males and females 9 through 26 years of age.