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A gene on chromosome 21q21.3 that encodes a cell surface receptor and transmembrane precursor protein which is cleaved by secretases to form various peptides.

Molecular pathology
APP mutations are implicated in autosomal dominant Alzheimer’s disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).


Amyloid beta peptide. It is the toxic peptide that causes damage to neurons in patients having Alzheimer disease.
References in periodicals archive ?
It is introduced into children, takes 30 years to develop, and then -- when they are in their 30s -- the blood vessels are completely loaded with amyloid beta, which destroys the vessels," Sebastian Bradner, a professor at University College London's Institute of Neurology and lead author of a study detailing the findings, told AFP.
Their findings suggest that higher levels of amyloid beta may be associated with increasing symptoms of anxiety in these individuals.
He examined the relationship between UPSIT and brain amyloid beta in 84 subjects, 58 of whom had mild cognitive impairment (MCI) at baseline.
O, propagating in a prion-like manner, but not plaque or amyloid beta monomer, are actually the primary drivers of neurodegeneration and cognitive decline in AD patients.
Kreisl examined the relationship between UPSIT and brain amyloid beta in 84 subjects, 58 of whom had mild cognitive impairment (MCI) at baseline.
The scientists showed that the mice that could produce amyloid beta had a much easier time fighting off salmonella infections and yeast infections in the brain.
Pu Wang, PhD, of Northeastern University in Shenyang, China, and colleagues tested the effect of magnesium threonate, which is believed to penetrate the blood/brain barrier, on normal mice and mice that overexpressed a gene that increased amyloid beta production while decreasing the influx of magnesium into the brain.
We have a new brain imaging method that can detect the toxin that leads to Alzheimer's disease," said Klein, who first identified the amyloid beta oligomer in 1998.
For the latest study in the Proceedings of the National Academy of Sciences, researchers looked at how copper in the capillaries may cause a breakdown in the blood-brain barrier, leading to a build-up of the protein amyloid beta, or plaques that are a hallmark of Alzheimer's.
The study showed that copper accumulating in the brain disrupted the natural removal of toxic amyloid beta protein, which is strongly implicated in Alzheimer's.
Published in the March 6, 2012 issue of the Journal of Alzheimer's Disease, the early findings show that vitamin D3 may activate key genes and cellular signaling networks to help stimulate the immune system to clear the amyloid beta protein.
It is becoming widely understood among experts in the field that the neurotoxic amyloid beta (AB) 42 peptide is a primary bad actor in the onset and progression of AD," said Hayden.