It is hoped people with amyloid beta
build-up could have drugs tested on them to prevent cell damage.
But newer research implicated the smaller aggregates of amyloid beta
as the toxic elements of this disease.
Cerebrospinal fluid (CSF) levels of amyloid beta
and tau are well studied as biomarkers associated with Alzheimer's disease (AD).
According to the two companies, this is the first late-stage anti-amyloid antibody study to demonstrate potential disease-modifying effects on both clinical function and amyloid beta
accumulation in the brain.
Their findings published in the American Journal of Psychiatry suggest that higher levels of amyloid beta
may be associated with increasing symptoms of anxiety in these individuals.
The results showed that a compound that boosts the function of the endosomal network significantly cuts the production of both amyloid beta
and a precursor of the Tau protein.
"It is introduced into children, takes 30 years to develop, and then -- when they are in their 30s -- the blood vessels are completely loaded with amyloid beta
, which destroys the vessels," Sebastian Bradner, a professor at University College London's Institute of Neurology and lead author of a study detailing the findings, told AFP.
The blood test opens the way for possibly far cheaper and less invasive tests for amyloid beta
, which builds up in the brain as Alzheimer's develops, said the researchers.
Mensinger et al., "Purified and synthetic Alzheimer's amyloid beta
(A[beta]) prions," Proceedings of the National Academy of Sciences of the United States of America, vol.
Of the 38 patients who were positive for amyloid beta
on either diagnostic test, 32 had an UPSIT score less than 35, while six had a score of 35 or greater.
According to William Kriesl, MD, poor UPSIT sores are also related to brain levels of amyloid beta
and are almost as predictive of cognitive decline.