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A gene on chromosome 21q21.3 that encodes a cell surface receptor and transmembrane precursor protein which is cleaved by secretases to form various peptides.

Molecular pathology
APP mutations are implicated in autosomal dominant Alzheimer’s disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Amyloid beta peptide. It is the toxic peptide that causes damage to neurons in patients having Alzheimer disease.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
It is hoped people with amyloid beta build-up could have drugs tested on them to prevent cell damage.
But newer research implicated the smaller aggregates of amyloid beta as the toxic elements of this disease.
Cerebrospinal fluid (CSF) levels of amyloid beta and tau are well studied as biomarkers associated with Alzheimer's disease (AD).
According to the two companies, this is the first late-stage anti-amyloid antibody study to demonstrate potential disease-modifying effects on both clinical function and amyloid beta accumulation in the brain.
Their findings published in the American Journal of Psychiatry suggest that higher levels of amyloid beta may be associated with increasing symptoms of anxiety in these individuals.
The results showed that a compound that boosts the function of the endosomal network significantly cuts the production of both amyloid beta and a precursor of the Tau protein.
"It is introduced into children, takes 30 years to develop, and then -- when they are in their 30s -- the blood vessels are completely loaded with amyloid beta, which destroys the vessels," Sebastian Bradner, a professor at University College London's Institute of Neurology and lead author of a study detailing the findings, told AFP.
The blood test opens the way for possibly far cheaper and less invasive tests for amyloid beta, which builds up in the brain as Alzheimer's develops, said the researchers.
Mensinger et al., "Purified and synthetic Alzheimer's amyloid beta (A[beta]) prions," Proceedings of the National Academy of Sciences of the United States of America, vol.
Of the 38 patients who were positive for amyloid beta on either diagnostic test, 32 had an UPSIT score less than 35, while six had a score of 35 or greater.
According to William Kriesl, MD, poor UPSIT sores are also related to brain levels of amyloid beta and are almost as predictive of cognitive decline.