Vancomycin is a tricyclic glycopeptide antibiotic derived from Amycolatopsis
orientalis (formerly Nocardia orientalis) used for serious gram positive infections.
Some studies also report the isolation of actinomycetes from different mines, which are difficult to isolate from other environments such as Nocardia, Amycolatopsis
, Isoptericola, Jiangella, Pseudonocardia (Groth et al.
INTRODUCTION: Vancomycin, a tricyclic glycopeptide antibiotic (C66H75C12N9024) first isolated from a soil bacterium Actinobacteria species Amycolatopsis
orientalis, acts by inhibiting the formation of the peptidoglycan polymers of the bacterial cell wall.
In contrast to the studies on Amycolatopsis
and fungal degradation of PLA, the reports on the bacterial degradation of PLA and the purification of the correlative enzyme from bacteria are relatively less.
Vancomycin is a branched tricyclic glycosylated nonribosomal peptide produced by the fermentation of Amycolatopsis
orientalis, and it used in the treatment of infections caused by Gram-positive bacteria.
For example, a 5-dehydroxymethyl derivative of epoxyquinomicin C, isolated from Amycolatopsis
has shown a significant growth inhibition in hormone-refractory PCA cell line DU-145 through the induction of a apoptotic cell death (Kikuchi et al.
In the vancomycin producer Amycolatopsis
Rifampicin or rifampin I is a semisynthetic compound derived from Amycolatopsis
rifamycinica (Sensi et al.