Amsterdam criteria


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Amsterdam criteria

The clinical criteria needed to diagnose hereditary nonpolyposis colorectal cancer (HNPCC—Lynch syndrome) in a family:
• There are at least three relatives with an HNPCC-associated cancer (large bowel, endometrium, small bowel, ureter or renal pelvis, but not stomach, ovary, brain, bladder or skin);
• One affected person is a first-degree relative of the other two;
• At least two successive generations are affected;
• At least one person was diagnosed before the age of 50 years;
• Familial adenomatous polyposis has been excluded;
• Tumours have been verified by pathologic examination.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Amsterdam criteria

Oncology Criteria for diagnosing hereditary nonpolyposis colorectal cancer, see there.
Amsterdam criteria
Family history
Presence of histologically verified colorectal cancer in ≥ 3 relatives–one of whom is a 1st-degree relative of the other 2
'Vertical' history
Presence of disease in ≥ 2 successive generations
Age of onset
Age < 50 in > 1 affected relative
Exclusion
Hereditary polyposis syndromes have been excluded
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Amsterdam criteria

(am′stĕr-dam″)
A means of screening family members for evidence of a hereditary predisposition to colorectal cancer. People in families with nonpolyposis colorectal cancer are screened for evidence of other malignancies of the skin, endometrium, and stomach. Those who meet the Amsterdam criteria should be closely followed, e.g., with regular colonoscopies.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Families meeting the Amsterdam Criteria but with no identifiable mutation should be labelled as 'familial colorectal cancer syndrome X' and be enrolled into appropriate screening programmes.
Further, ten families of colorectal cancers (11.1%) did not meet all of Amsterdam criteria, but they had colorectal cancers in two generations.
Subsequently, we investigated the MLH1 and MSH2 genes of patients fulfilling the Amsterdam criteria prospectively by the BESS protocol.
Amsterdam Criteria Amsterdam Criteria I, 1990 At least 3 relatives with colorectal cancer: 1.
Almost half of all patients with HNPCC can be identified through family history, and this fact has been incorporated in two sets of clinical criteria, known as the Bethesda criteria and the modified Amsterdam criteria. The latter is the simpler of the two, recommending genetic testing if these three criteria are met:

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