DST

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DST

A gene on chromosome 6p12.1 that encodes dystonin, a cytoskeletal linker protein which integrates intermediate filaments, actin and the microtubule cytoskeleton network, and is required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional reticulum.

DST isoform 3 plays a structural role in assembling hemidesmosomes of epithelial cells; it anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes and is required for regulating keratinocyte polarity and motility; it mediates integrin ITGB4 regulation of RAC1 activity. DST isoform 6 is required for bundling actin filaments around the nucleus. DST isoform 7 regulates the organisation and stability of the microtubule network of sensory neurons to allow axonal transport.

Molecular pathology
Defects of DST cause hereditary sensory and autonomic neuropathy type 6.
References in periodicals archive ?
Joining Ampex Brands in the operation and growth of the Tim Hortons restaurants in Columbus is Mike Forbes, a restauranteur who has been a Tim Hortons restaurant owner, along with his wife Trina, since 1999.
The sunroom study in the house where I grew up with my brother and sister was a mini-playback studio, with an Ampex quarter-track reel-to-reel deck, on which Dad's demos and finished product were played.
Televised replay made its debut during the December 7, 1963, Army-Navy football game when 29-year-old CBS director Tony Verna, who passed away January 18, 2015, at the age of 81, pressed "rewind" on his Ampex tape machine for the first time during a game broadcast.
Back in 1977, Sunjay's dad recorded one of Roger's concerts on to an Ampex professional audio tape.
I swapped an Ampex 350 1/4'' tape recorder from Pye Studios with a maintenance engineer who used to work at Olympic studios.
(65) Ampex Corporation, for example, was founded in 1944 and enjoyed decades of growth in the audio/video industry thanks to its groundbreaking innovations.
En este disco, Herren decidio transferir todas sus grabaciones a cinta analogica--en concreto, a cinta Ampex, de ahi el titulo del disco--, como una reaccion a la idea de control y perfeccion que otorgan las herramientas digitales.
(199.) This point is cogently made in In re Ampex Corp., No.
Ampex and one or two other American firms developed the basic concepts.
Las exportaciones, han venido en constante aumento, en 2006 se exportaron 5 t con un valor de US$22,817.05 (Ampex, 2008) y para 2010, las exportaciones alcanzaron 15,35 t con valor de US$148,296.55, principalmente como fruto deshidratado.
LAHORE -- A Memorandum of Understanding has been inked between Tourism Development Cooperation Punjab and an Austrian firm Apolo Ampex to establish 300 acre Theme and Entertainment Park on Khanpur Canal, district Sheikhupura in close vicinity to Shahdara Lahore.