ampakines

A class of drugs that act on nerve cell receptors to make them more responsive to the NEUROTRANSMITTER glutamate. Ampakines alter the ways in which a memory is encoded and modify the strength of the memory trace. A few small clinical trials have suggested that ampakines can significantly improve memory in elderly people. The duration of action is short.

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May 04, 2015: Cortex Pharmaceuticals Announces Publication of Research Results on the Use of Ampakines CX1739 in the Treatment of Respiratory Disorders 70

Pompe Disease - Pipeline Review, H2 2015 Is Released

Ampakines had previously been shown to improve age-related cognitive deficits in rats as well as increase production of a key growth factor, brain-derived neurotrophic factor (BDNF) in the brain.

Drug Prevents Key Age-Related Brain Change in Rats

Cortex Pharmaceuticals added that the proceeds may be used to support its clinical development of ampakines for the treatment of central sleep apnea and opiate induced respiratory depression, commencing with a Phase 2A clinical study of CX1739, the lead ampakine, as well as to fund corporate general and administrative costs.

Cortex Pharmaceuticals raises USD721,180 from initial closing of private placement

Ampakines have been studied by the Defense Advanced Research Projects Agency (DARPA) for use by the military.

Treading in the sea of data: information: our world is swimming in it. With each passing day, our lives become more dependent on it. Yet, the very magnitude of this torrent of data compromises its benefits to us. New strategies and technologies are now evolving that may save us from drowning--and even help us thrive

Ampakines, a new class of drugs developed by Lynch, are currently in clinical development for Alzheimer's disease and attention-deficit hyperactivity disorder (ADHD).

Images reveal brain changes associated with memory

Studies of cells in the laboratory have shown that drugs called ampakines elevate production of BDNF.

Total recall: drug shows long-lasting boosts of memory in rats

Scientists in California are developing a class of experimental drugs call ampakines which flood the brain with a neurotransmitter that makes learning easy, improves memory and boosts alertness.

Miriam: BRAIN BOOSTER

The drugs - called ampakines - work by boosting the levels of a brain chemical that makes it easier to learn and create memoriesDr Gary Lynch, who discovered the drug, explained: 'We all have the same computer but we're running with different voltage levels.

THE SMART PILL; Booster is Viagra for brain

This brings our total portfolio on the AMPAKINEs to 17 issued and allowed patents, with 58 additional patent applications in various stages of review throughout the world.

Cortex receives additional Ampakine patents and notices of allowance

Greer stated, "It is striking how well AMPAKINES enhance the activity of brain cells in the respiratory rhythm generator.

Cortex Receives U.S. Patent for the Use of AMPAKINE Molecules to Treat Respiratory Depression

ONE US company has been working on a class of drugs called ampakines.

Dr Miriam: Memory's on the blink

Research conducted at the University of California, Irvine (Irvine, CA) demonstrates that AMPAKINEs can increase the production of the important neurotrophic factors BDNF (brain derived neurotrophic factor) and NGF (neuronal growth factor) in critical areas of the brain involved in memory.