ampakines

A class of drugs that act on nerve cell receptors to make them more responsive to the NEUROTRANSMITTER glutamate. Ampakines alter the ways in which a memory is encoded and modify the strength of the memory trace. A few small clinical trials have suggested that ampakines can significantly improve memory in elderly people. The duration of action is short.

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The nootropic segment by types is further segmented into racetams, ampakines, choline & acetylcholine intermediates, others.

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Ampakines. The second platform of proprietary medicines being developed by RespireRx are ampakines, which act to enhance the actions of the excitatory neurotransmitter glutamate at AMPA glutamate receptors.

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In that regard, ampakines are experimental drugs that have been shown to improve opioid-induced ventilation without loss of the analgesic effect (Clin Pharmacol Ther.

Treating sleep disorders in chronic opioid users

[2] Some various drug groups that are approved by the US Food and Drug Administration are racetam, cholinergics, acetylcholinesterase inhibitors, AMPAkines, smart drugs, dopaminergics, nootropic vitamins, and neurohormones.

The effect of pramiracetam in the myelination of the hippocampus in the BALB/c mouse (Mus musculus)

May 04, 2015: Cortex Pharmaceuticals Announces Publication of Research Results on the Use of Ampakines CX1739 in the Treatment of Respiratory Disorders 70

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The team, led by Lynch, Julie Lauterborn, and Linda Palmer, wanted to know whether dendritic retraction was already underway in 13-month-old or "middle-aged" rats and, if it was, could they reverse it by giving rats a compound called an ampakine. Ampakines had previously been shown to improve age-related cognitive deficits in rats as well as increase production of a key growth factor, brain-derived neurotrophic factor (BDNF) in the brain.

Drug Prevents Key Age-Related Brain Change in Rats

Cortex Pharmaceuticals added that the proceeds may be used to support its clinical development of ampakines for the treatment of central sleep apnea and opiate induced respiratory depression, commencing with a Phase 2A clinical study of CX1739, the lead ampakine, as well as to fund corporate general and administrative costs.

Cortex Pharmaceuticals raises USD721,180 from initial closing of private placement

Gall, "Ampakines and the Threefold Path to Cognitive Enhancement," Trends in Neuroscience 29 (2006): 554-62.

Moral enhancement as a technological imperative

Ampakines, for instance, are a new class of compounds that improve attention span and alertness as well as facilitating learning and memory.

Treading in the sea of data: information: our world is swimming in it. With each passing day, our lives become more dependent on it. Yet, the very magnitude of this torrent of data compromises its benefits to us. New strategies and technologies are now evolving that may save us from drowning--and even help us thrive

Ampakines, a new class of drugs developed by Lynch, are currently in clinical development for Alzheimer's disease and attention-deficit hyperactivity disorder (ADHD).

Images reveal brain changes associated with memory

Studies of cells in the laboratory have shown that drugs called ampakines elevate production of BDNF.

Total recall: drug shows long-lasting boosts of memory in rats

Scientists in California are developing a class of experimental drugs call ampakines which flood the brain with a neurotransmitter that makes learning easy, improves memory and boosts alertness.