These patents are key for developing the AMPAKINE
technology for the potential treatment of a variety of clinical indications."
Additionally, the companies have signed a memorandum of understanding (MOU) for the rights to the AMPAKINE
CX1739 for neurodegenerative diseases in South Korea.
29 March 2010 - US-based developer of small molecule compounds Cortex Pharmaceuticals Inc (OTC: CORX) announced on Friday that it has entered into an agreement with Biovail Laboratories International SRL in which Biovail acquired certain AMPAKINE
compounds and the rights to the patent filing for respiratory depression and vaso-occlusive crises associated with sickle cell disease.
(Irvine, CA; 949-727-3157) announced that it has received three patents and three notices of allowances for patents in its AMPAKINE
M2 EQUITYBITES-August 25, 2011-Cortex Pharmaceuticals Inc awarded US patent for AMPAKINE
molecules for respiratory depression(C)2011 M2 COMMUNICATIONS http://www.m2.com
"Cortex and its collaborators at UC Irvine are in the process of initiating a long term experiment in which rats will receive an AMPAKINE
in their drinking water for four to eight months.
M2 EQUITYBITES-August 25, 2011-Cortex awarded patent for the use of AMPAKINE
molecules to treat respiratory depression(C)2011 M2 COMMUNICATIONS http://www.m2.com
For example, treatment of healthy human subjects with an ampakine
, which enhances LTP, improved performance in a dose-dependent manner.
There also is evidence that ampakine
, an investigational drug that modulates glutaminergic alpha-amino-3-hydroxy-5methylisoxazole-4-propionic acid (AMPA) receptor activity, improves "many domains of cognitive function," Dr.
The team, led by Lynch, Julie Lauterborn, and Linda Palmer, wanted to know whether dendritic retraction was already underway in 13-month-old or "middle-aged" rats and, if it was, could they reverse it by giving rats a compound called an ampakine
had previously been shown to improve age-related cognitive deficits in rats as well as increase production of a key growth factor, brain-derived neurotrophic factor (BDNF) in the brain.
Cortex Pharmaceuticals added that the proceeds may be used to support its clinical development of ampakines
for the treatment of central sleep apnea and opiate induced respiratory depression, commencing with a Phase 2A clinical study of CX1739, the lead ampakine
, as well as to fund corporate general and administrative costs.
Katz, "Brain-derived neurotrophic factor expression and respiratory function improve after ampakine
treatment in a mouse model of Rett syndrome," The Journal of Neuroscience, vol.