ampakine

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ampakine

An AMPA-type glutamine receptor agonist (e.g., CX516) which facilitates synaptic transmission by binding to glutamate and enhancing long-term potentiation, a critical component in memory. Amakines enhance the activity of AMPA receptor-rich neurons by amplifying neural signals, and are reported to improve memory in early trials in Alzheimer’s disease and schizophrenia.

ampakine

Neuropharmacology Any compound that facilitates synaptic transmission by binding to glutamate and enhance long-term potentiation, a critical component in long term memory, by enhancing the activity of AMPA receptor-rich neurons which enhance AMPA receptor activity by amplifying neural signals generated by glutamate binding; ampakines improve memory in early trials in Alzheimer's disease, schizophrenia See AMPA receptor, Long-term potentiation.

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The team, led by Lynch, Julie Lauterborn, and Linda Palmer, wanted to know whether dendritic retraction was already underway in 13-month-old or "middle-aged" rats and, if it was, could they reverse it by giving rats a compound called an ampakine.

Drug Prevents Key Age-Related Brain Change in Rats

Cortex Pharmaceuticals added that the proceeds may be used to support its clinical development of ampakines for the treatment of central sleep apnea and opiate induced respiratory depression, commencing with a Phase 2A clinical study of CX1739, the lead ampakine, as well as to fund corporate general and administrative costs.

Cortex Pharmaceuticals raises USD721,180 from initial closing of private placement

Drugs like Ampakine CX717 may prevent harmful effects of sleep deprivation and enhance attention span and alertness.

Industry's vital role in national cyber security

As previously announced, in June 2011 Cortex entered into a new agreement with Servier to sell its remaining rights to the jointly discovered AMPAKINE compound, CX1632.

Cortex net loss drops to USD356,000 in Q2 2011

Randomized, double-blind, placebo-controlled international clinical trial of the Ampakine CX516 in elderly participants with mild cognitive impairment: a progress report.

Deterioro cognitivo ligero, ?una entidad necesaria?

One ampakine is currently being tested in people with Alzheimer's disease.

Total recall: drug shows long-lasting boosts of memory in rats

Increased net losses in the current year periods reflect development expenses for the AMPAKINE(R) compound, CX717 and increased preclinical research and development of the AMPAKINE technology.

CORTEX REPORTS 2ND QTR NET LOSS OF $2,689,000

Unfortunately, the first generation drug faltered in clinical trials but the firm is moving ahead with a more potent ampakine, CX717.

Dr Miriam: Memory's on the blink

For example, treatment of healthy human subjects with an ampakine, which enhances LTP, improved performance in a dose-dependent manner.

Monitoring and manipulating brain function: new neuroscience technologies and their ethical implications

There also is evidence that ampakine, an investigational drug that modulates glutaminergic alpha-amino-3-hydroxy-5methylisoxazole-4-propionic acid (AMPA) receptor activity, improves "many domains of cognitive function," Dr.

Cognitive deficits affect 85% of schizophrenics. (Deficits are Often Profound)

These AMPAKINE compounds are a very interesting class of molecules," said Vincent F.

Cortex Pharma receives notice of allowance of European patent

It was invented at UC Irvine - an ampakine compound trademarked as a pill under the name Ampalex.