amoxicillin

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amoxicillin

 [ah-moks″ĭ-sil´in]
an antibiotic that is a penicillin analogue similar in action to ampicillin but more efficiently absorbed from the gastrointestinal tract and therefore requiring less frequent dosage and not as likely to cause diarrhea.

amoxicillin, amoxicillin trihydrate

Amix (UK), Amox (CA), Amoxident (UK), Amoxil, Apo-Amoxil (CA), Moxatag (CA), Novamoxin (CA), Nu-Amoxil (CA), Trimox

Pharmacologic class: Aminopenicillin

Therapeutic class: Anti-infective

Pregnancy risk category B

Action

Inhibits cell-wall synthesis during bacterial multiplication, leading to cell death. Shows enhanced activity toward gram-negative bacteria compared to natural and penicillinase-resistant penicillins.

Availability

Capsules: 250 mg, 500 mg

Powder for oral suspension: 50 mg/ml and 125 mg/5 ml (pediatric), 200 mg/5 ml, 250 mg/5 ml, 400 mg/5 ml

Tablets: 500 mg, 875 mg

Tablets for oral suspension: 200 mg, 400 mg

Tablets (chewable): 125 mg, 200 mg, 250 mg, 400 mg

Indications and dosages

Uncomplicated gonorrhea

Adults and children weighing at least 40 kg (88 lb): 3 g P.O. as a single dose

Children ages 2 and older weighing less than 40 kg (88 lb): 50 mg/kg P.O. given with probenecid 25 mg/kg P.O. as a single dose

Bacterial endocarditis prophylaxis for dental, GI, and GU procedures

Adults: 2 g P.O. 1 hour before procedure

Children: 50 mg/kg P.O. 1 hour before procedure

Lower respiratory tract infections caused by streptococci, pneumococci, non-penicillinase-producing staphylococci, and Haemophilus influenzae

Adults and children weighing more than 20 kg (44 lb): 875 mg P.O. q 12 hours or 500 mg P.O. q 8 hours

Children weighing less than 20 kg (44 lb): 45 mg/kg/day P.O. in divided doses q 12 hours or 40 mg/kg/day P.O. in divided doses q 8 hours

Ear, nose, and throat infections caused by streptococci, pneumococci, non-penicillinase-producing staphylococci, and H. influenzae; GU infections caused by Escherichia coli, Proteus mirabilis, and Streptococcus faecalis

Adults and children weighing more than 20 kg (44 lb): 500 mg P.O. q 12 hours or 250 mg P.O. q 8 hours

Children weighing less than 20 kg (44 lb): 45 mg/kg/day P.O. in divided doses q 12 hours or 20 to 40 mg/kg P.O. in divided doses q 8 hours

Eradication of Helicobacter pylori to reduce risk of duodenal ulcer recurrence

Adults: 1 g P.O. q 12 hours for 14 days in combination with clarithromycin and lansoprazole, or in combination with lansoprazole alone as 1 g t.i.d. for 14 days

Postexposure anthrax prophylaxis

Adults: 500 mg P.O. t.i.d. for 60 days

Children: 80 mg/kg/day P.O. t.i.d. for 60 days

Skin and skin-structure infections caused by streptococci (alpha- and beta-hemolytic strains), staphylococci, and E. coli

Adults: 500 mg P.O. q 12 hours to 250 mg P.O. q 8 hours. For severe infections, 875 mg P.O. q 12 hours or 500 mg P.O. q 8 hours.

Children older than age 3 months: 25 mg/kg/day P.O. in divided doses q 12 hours or 20 mg/kg/day P.O. in divided doses every 8 hours. For severe infections, 45 mg/kg/day P.O. in divided doses q 12 hours or 40 mg/kg/day P.O. in divided doses every 8 hours.

Dosage adjustment

• Renal impairment

• Hemodialysis

• Infants ages 3 months and younger

Off-label uses

Chlamydia trachomatis infection in pregnant patients

Contraindications

• Hypersensitivity to drug or any penicillin

Precautions

Use cautiously in:

• severe renal insufficiency, infectious mononucleosis, hepatic dysfunction

• pregnant patients.

Administration

Ask about history of penicillin allergy before giving.

• Give with or without food.

• Store liquid form in refrigerator when possible.

• Know that maximum dosage for infants ages 3 months and younger is 30 mg/kg/day divided q 12 hours.

Adverse reactions

CNS: lethargy, hallucinations, anxiety, confusion, agitation, depression, dizziness, fatigue, hyperactivity, insomnia, behavioral changes, seizures (with high doses)

GI: nausea, vomiting, diarrhea, bloody diarrhea, abdominal pain, gastritis, stomatitis, glossitis, black "hairy" tongue, furry tongue, enterocolitis, pseudomembranous colitis

GU: vaginitis, nephropathy, interstitial nephritis

Hematologic: eosinophilia, anemia, thrombocytopenia, thrombocytopenic purpura, leukopenia, hemolytic anemia, agranulocytosis, bone marrow depression

Hepatic: cholestatic jaundice, hepatic cholestasis, cholestatic hepatitis, nonspecific hepatitis

Respiratory: wheezing

Skin: rash

Other: superinfections (oral and rectal candidiasis), fever, anaphylaxis

Interactions

Drug-drug. Allopurinol: increased risk of rash

Chloramphenicol, macrolides, sulfonamides, tetracycline: decreased amoxicillin efficacy

Hormonal contraceptives: decreased contraceptive efficacy

Probenecid: decreased renal excretion

Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, eosinophils, lactate dehydrogenase: increased levels

Granulocytes, hemoglobin, platelets, white blood cells: decreased values Direct Coombs' test, urine glucose, urine protein: false-positive results

Drug-food. Any food: delayed or reduced drug absorption

Drug-herbs. Khat: decreased antimicrobial efficacy

Patient monitoring

• Monitor for signs and symptoms of hypersensitivity reaction.

Evaluate for seizures when giving high doses.

• Monitor patient's temperature and watch for other signs and symptoms of superinfection (especially oral or rectal candidiasis).

Patient teaching

Instruct patient to immediately report signs and symptoms of hypersensitivity reactions, such as rash, fever, or chills.

• Tell patient he may take drug with or without food.

• Tell patient not to chew or swallow tablets for suspension, because they're not meant to be dissolved in mouth.

• Advise patient to minimize GI upset by eating small, frequent servings of food and drinking plenty of fluids.

• Tell patient taking hormonal contraceptives that drug may reduce contraceptive efficacy. Suggest she use alternative birth control method.

• Inform patient that drug lowers resistance to other types of infections. Instruct him to report new signs and symptoms of infection, especially in mouth or rectum.

• Tell parents they may give liquid form of drug directly to child or may mix it with foods or beverages.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, and herbs mentioned above.

a·mox·i·cil·lin

(ă-mok'si-sil'in),
A semisynthetic penicillin antibiotic with an antimicrobial spectrum similar to that of ampicillin.

amoxicillin

(ə-mŏk′sĭ-sĭl′ĭn)
n.
A semisynthetic penicillin, C16H19N3O5S, having an antibacterial spectrum of action similar to that of ampicillin.

amoxicillin

Infectious disease A broad-spectrum semisynthetic penicillin with activity similar to that of ampicillin

amoxicillin

Amoxycillin, an AMPICILLIN-like penicillin antibiotic, effective in TYPHOID and many other infections. Brand names are Amoxil and Galenamox. Compounded with lansoprazol and clarithromycin it is marketed as Heliclear.

a·mox·i·cil·lin

(ă-mok'si-sil'in)
A semisynthetic penicillin antibiotic with an antimicrobial spectrum similar to that of ampicillin.
References in periodicals archive ?
Os quatro medicamentos mais usados na amostra analisada (paracetamol, amoxicilina, dipirona e ibuprofeno) possuem uma boa documentacao para o uso pediatrico, embora a indicacao nao seja recomendada em algumas faixas etarias (23,24).
+ Trimetoprim 44 4 1 Clindamicina 42 7 0 Gentamicina 41 2 6 Norfloxacina 40 8 1 Enrofloxacina 39 7 3 Cloranfenicol 38 9 2 Eritromicina 37 7 5 Cefoxitina 33 4 12 Oxacilina 28 0 21 Neomicina 24 18 7 Tetraciclina 24 13 12 Cefoperazone 19 21 9 Ampicilina 1 3 45 Amoxicilina 1 0 48 Penicilina 0 1 48 Sensivel Intermediario Resistente Cefalexina 42 2 1 Cefalotina 41 2 2 Ceftiofur 41 1 3 Sulfa.
Las cepas resistentes al mercurio mostraron resistencia a ampicilina, tetraciclina, amoxicilina y sulfametoxazoltrimetoprim; Cardonha et al.
Los mayores porcentajes de resistencia se observaron para los antibioticos betalactamicos: amoxicilina y cefalexina.
En cuanto a desenlaces secundarios, hubo mayor riesgo de aneurisma de aorta en el grupo de fluoroquinolonas comparado con el de amoxicilina (HR 1,9; IC 95%, 1,22-2,96) mas no mayor riesgo de diseccion aortica (HR 0,93; IC 95%, 0,38-2,29).
coli fue amoxicilina, cefuroxima, florfenicol, enrofloxacina, oxitetraciclina y trimetoprima / sulfametoxazol (en 5 aislamientos); para la E.
El aceite esencial de Minthostachys mollis, presento efectos antibacterianos frente a cepas de Staphylococcus aureus y Klebsiella pneumoniae a una concentracion de 50 [micron]g/mL, evidenciandose por la formacion de halos como expresion de la inhibicion del crecimiento bacteriano; la amoxicilina + acido clavulanico, que es el farmaco mas utilizado contra esta bacteria, fue utilizado como control en el presente trabajo, inhibio el crecimiento bacteriano a una concentracion de 30 [micron]g/mL, observandose que el estandar tiene mayor efecto que el aceite esencial.
En general, las bacterias Gram negativas tales como Chryseobacterium y Pseudomonas, presentan resistencia innata a muchos antibioticos (Poole, 2005; Sakurada, 2008), pero no observamos ninguna resistencia a oxitetraciclina, gentamicina, florfenicol, amoxicilina, sulfatrimet o cefapirina.
Susceptibilidad a antibioticos: En el screening inicial para buscar aislados del genero Salmonella potencialmente candidatos a la produccion de enzimas inactivantes de antibioticos, se encontro que 100% de cepas de Salmonella aisladas fueron sensibles a trimetoprima--sulfametoxazol y ciptofloxacina mientras que el 9,5% (2/21 cepas) mostraron resistencia ante la amoxicilina. Las dos cepas que resultaron resistentes a Amoxicilina, mostraron un comportamiento de susceptibilidad y resistencia similar ante todos los antimicrobianos probados, como se observa en la (Tabla I); por lo que se decidio evaluar dicha resistencia con la finalidad de encontrar mecanismos involucrados relacionados con la produccion de [beta]-lactamasas de espectro extendido.
La amoxicilina es un antibiotico derivado de la penicilina y es ampliamente utilizado para tratar una gran cantidad de infecciones causadas por bacterias.
Apos um ano dos sintomas iniciais, surgiram pustulas cutaneas na face, uma delas evoluiu com abscesso fistulizado, resolvido apos tratamento com amoxicilina por sete dias.
Contract awarded for acquisition amoxicilina, dicloxacillin, doxycycline, address for area health guatemala sur