amoxapine


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amoxapine

 [ah-mok´sah-pēn]
a tricyclic antidepressant of the dibenzoxazepine class; administered orally.

amoxapine

A tricyclic antidepressant of the dibenzoxazepine class.
 
Adverse effects
Tardive dyskinesia, sedation, postural hypotension, cholinergic effects (e.g., dry mouth, blurred vision, constipation, urinary retention, weight gain), neuroleptic malignant syndrome, cardiovascular effects (EKG, slow AV conduction); withdrawal symptoms accompany abrupt withdrawal.
 
Toxic range
> 500 ng/mL.
 
T1/2
30 hours as metabolite (8-hydroxyamoxipine).
 
Method
HPLC.

amoxapine

Neuropharmacology A tricyclic antidepressant Adverse effects Tardive dyskinesia, sedation, postural hypotension, cholinergic effects—eg dry mouth, blurred vision, constipation, urinary retention, weight gain, neuroleptic malignant syndrome, cardiovascular effects—EKG, slow AV conduction; withdrawal symptoms accompany abrupt withdrawal

amoxapine

A tricyclic antidepressant drug similar to IMIPRAMINE. Overdosage may cause acute kidney failure, convulsions and coma. A brand name is Asendis.
References in periodicals archive ?
Tricyclic Antidepressants: Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Trimipramine
Table 1 Medications that can cause serotonin syndrome Action Medications Increases serotonin Tryptophan formation Increases release of Amphetamines and amphetamine derivatives serotonin Cocaine MDMA Impairs serotonin Cocaine, MDMA, meperidine, reuptake tramadol, pentazocine SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) SNRIs (desvenlafaxine, duloxetine, milnacipran, venlafaxine, levomilnacipran) Dopamine-norepinephrine reuptake inhibitors (bupropion) Serotonin modulators (nefazodone, trazodone, vilazodone, vortioxetine) TCAs (amitriptyline, amoxapine, clomipramine, desipramine, doxepin) St.
Pies, MD, because loxapine is converted into amoxapine (an antidepressant), it could benefit patients with psychosis and depression.
The National Pregnancy Registry for Antidepressants (844-405-6185) is studying amitriptyline (Elavil), amoxapine (Asendin), bupropion (Forfivo XL and Wellbutrin), Citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), desvenlafaxine (Prisiq), doxepin (Sinequan), escitalopram (Lexapro), fluvoxamine (Luvox), fluoxetine (Prozac), imipramine (Tofranil), isocarboxazid (Marplan), levomilnacipran (Fetzima), maprotiline (Ludiomil), mirtazapine (Remeron), nefazodone (Serzone), nortriptyline (Pamelor), paroxetine (Paxil), phenelzine (Nardill), protriptyline (Vivactil), selegiline (Emsam), sertraline (Zoloft), tranylcypromine (Parnate), trazodone (Desyrel), trimipramine (Surmontil), venlafaxine (Effexor), and vilazodone (Viibryd).
Osterberg, "The neuropharmacological actions of amoxapine," Archives Internationales De Pharmacodynamie Et De Therapie, vol.
--simultaneous administration of other drugs with action upon D2 receptors, such as: Metoclopramide, anticholinergic medication, lithium, Amoxapine, Promethazine, Prochlorperazine (3, 4, 5, 6).
Investigations into [beta]-glucuronidase inhibitors are in progress, some involving a synthetic compound in the experimental stage [47, 48] and others involving known drugs used to treat depression, such as nialamide, phenelzine, and amoxapine [49, 50].
Did not observe use of the following antidepressants: Amoxapine, Clomipramine, Imipramine, Maprotiline, Protriptyline, Trimipramine, Vilazodone, Vortioxetine, and Nefazodone.
Various antidepressant drugs have a piperazine nucleus such as amoxapine, befuraline.
In this group, reboxetine (2 mg) showed the maximum price variation of 900%, while amoxapine (50 mg) showed the minimum price variation of 17.72%.
The unit currently manufactures 2 TPM 1- Acetyl Naphthalene, 1 TPM 2- Acetyl Naphthalene, 6 TPM itopide HCl, 1.20 TPM loxapine succinate, 0.30 TPM amoxapine, 6 TPM venlafaxine, 6 TPM progunil HCl, 6 TPM CB-2-L-Valine, 0.60 TPM nateglinide, 0.60 TPM quetiapine, 24 TPM carbomazepin and 12 TPM oxacarbomazepin.
Measurement of plasma concentrations: Sample preparation for analysis consisted of adding 300 [micro]L of acetonitrile containing 100 ng/mL amoxapine (100%, Sigma-Aldrich, St Louis, MO, USA), which served as the internal standard, to 100 [micro]L of parrot plasma in a 96-well, 1-mL protein precipitation filter plate (Thermo Scientific, Waltham, MA, USA).