This property should be taken in consideration when developing high-energy solid dosage forms such as salts, co-crystals or amorphous solid
dispersions because there are specific thermodynamic and kinetic aspects that influence the dissolution behavior of these solid forms.
Although amorphous solid
dispersions to an extent are still considered non-conventional, there are now many commercial pharmaceutical products, which are based on solid dispersion technologies, some examples of which are provided in Table 2.
Compound 2 was also isolated as white amorphous solid
, whose UV and IR data were exactly similar to that of 1.
Compound 7e was obtained as white amorphous solid
having molecular formula C16H18ClNSO2.
Compound 1 was isolated as colorless amorphous solid
White amorphous solid
(13 mg); IR (KBr) nmax cm : 3565, 1743, 1241; H-NMR (CD3OD, 400 MHz) d: 7.
Crystals consist of atoms arranged in an ordered lattice that repeats itself, while amorphous solids
are completely chaotic.
It permits theanalysis and characterization of opaque and high light-scattering materials particularly powders (metals, drugs and insulators), suspensions (algae, bacteria and cell organelles), gels (films), amorphous solids
(glasses), and tissues (skinand leaf).
He then outlines applications of methods to materials like crystalline solids, disordered substitutional alloys, amorphous solids
, nanoclusters, nanowires, graphene, topological insulators, battery materials, spintronic materials, and materials under extreme conditions.
His main area of research interest has been the structure and properties of liquid metals and semiconductors, ionic fluids, glasses and amorphous solids
and he has published over 180 papers.
The aqueous phase is comprised of water and an organic dispersion stabilizer that contains a network of amorphous solids
, crystals, a liquid crystalline phase, or mixtures of said solids, crystals or liquid crystalline phase.