series was initially identified by Griffith University scientists in Australia as part of MMV's extensive malaria screening campaign of around 6 million compounds.
[AP] and 3,4-diaminopyridine [DAP]) are potassium channel blockers shown to improve nerve conduction in experimentally demyelinated axons.
is currently on the FDA's compounding for compassionate use list for treatment of certain neuropathies and for spinal cord injury and MS.
In March 2012, oppositions were filed with the European Patent Office (EPO) challenging a European patent granted in 2011 with claims relating to, among other things, use of a sustained release aminopyridine
composition, such as dalfampridine, to increase walking speed.
Jay Meythaler, head of NRI's Scientific Advisory Board, commented, "We are very excited to move into a Phase III pivotal trial for our version of 4- Aminopyridine
, Ampydin (IR), for the treatment of chronic functional motor and sensory deficits resulting from Guillain-Barre Syndrome.