aminopeptidases


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aminopeptidases

Enzymes that break the peptide bond of the amino acid at the end of a POLYPEPTIDE chain. Aminopeptidases occur in the small intestine and participate in the digestive breakdown of proteins to free amino acids.
References in periodicals archive ?
About Tosedostat Tosedostat is an oral aminopeptidase inhibitor that has demonstrated anti-tumor responses in blood-related cancers and solid tumors in Phase 1-2 clinical trials.
Properties of rat brain dipeptidyl aminopeptidases in the presence of detergents.
Characterization of membrane-bound aminopeptidases from rat brain: identification of the enkephalin-degrading aminopeptidase.
The significance of aminopeptidases and haematopoietic cell differentiation.
This has truly been a transformative last 12 months for CTI having secured two major development and commercialization collaborations; completed enrollment in the first Phase 3 clinical trial for pacritinib, which we believe is on track to report top-line results in the first quarter of 2015; initiated enrollment in the second Phase 3 trial for pacritinib; and secured worldwide rights to tosedostat, a first-in-class aminopeptidase inhibitor.
Enquiries Chroma Therapeutics Limited Ian Nicholson Chief Executive Officer +44 (0)1235 829120 Richard Bungay Chief Financial Officer Brunswick Jon Coles +44 (0)20 7404 5959 Justine McIlroy About aminopeptidases and CHR-2797
The new concept is based on the combined inhibition of alanyl aminopeptidases and dipeptidyl aminopeptidase IV which are playing a crucial role in regulating immunosuppressive mechanisms.
ABSTRACT Leucine aminopeptidase (LAP) belongs to a family of ubiquitous peptidases, with roles in growth and development, stress responses and adaptation to changing environmental conditions.
Tosedostat is an oral aminopeptidase inhibitor that has demonstrated significant anti-tumor responses in blood-related cancers and solid tumors in Phase 1-2 clinical trials.
CHR-2797 is the only oral aminopeptidase inhibitor currently in clinical development.