aminoglutethimide

aminoglutethimide

 [ah-me″no-gloo-teth´ĭ-mīd]

an antihormone that inhibits conversion of cholesterol to pregnenolone, thus reducing adrenocortical steroid synthesis; administered orally in treatment of cushing's syndrome. It also inhibits conversion of androstenedione to estrone in peripheral tissues and is sometimes used as a componnt of hormonal therapy for advanced breast carcinoma.

aminoglutethimide

Oncology A nonsteroidal aromatase inhibitor which inhibits estrogen production and suppresses estrogen-dependent tumor growth. See Estrogen-receptor.