Rodriguez performed many laborious experiments in which she removed portions of the aminoacyl-tRNA synthetase that interact with the anticodon stem of the transfer RNA, far from the part of the enzyme that binds the amino acid.
In all, Rodriguez found that separately removing seven different "gears" from a distant part of the molecule each caused the amino acid to bind more tightly to the aminoacyl-tRNA synthetase.
To illustrate the power of matching against secondary structure predictions, we present a novel proposed protein alignment, found using this system, for the protein class of aminoacyl-tRNA synthetases.
The aminoacyl-tRNA synthetases help establish the rules of the genetic code, by mediating the translation of DNA to protein.
Therefore, an RNA-only-based protein synthesis system would require a set of RNA molecules capable of synthesizing aminoacyl-RNAs, which are produced by the protein aminoacyl-tRNA synthetases
in extant biology.
The correct amino acid is attached to each tRNA species by specific enzymes called aminoacyl-tRNA synthetases
9:30 INVESTIGATING TRNA CHANNELING BY AMINOACYL-TRNA SYNTHETASES AND ELONGATION FACTOR TU
In these 36 reports, contributors describe their most recent research in aminoacyl-tRNA synthetases
, the point in gene expression in which the genetic code is first defined.
Furthermore, the full complement of aminoacyl-tRNAs necessary for translation is not entirely formed by the aminoacyl-tRNA synthetases
Antibacterial activity will be achieved through inhibition of essential aminoacyl-tRNA synthetases
11:00 Size Identification of Aminoacyl-tRNA Synthetases
The existence of a complex of aminoacyl-tRNA synthetases
in plants is still in question.