aminoacyl-tRNA synthetase

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aminoacyl-tRNA synthetase

Any of a class of enzymes (e.g., phenylalanyl-tRNA synthetase) that charge tRNAs with a cognate amino acid.

aminoacyl-tRNA synthetase

One of a group of 20 enzymes each of which is specific for the catalyzation of the linkage of a particular AMINO ACID to its own type of TRANSFER RNA during protein synthesis. There are 20 amino acids in body proteins.
References in periodicals archive ?
Discovered in 2003, this is the first example of an aminoacyl tRNA synthetase being implicated in any inherited human disorder, and so far 11 pathogenic missense GARS variants have been linked to not only dSMA-V but also Charcot-Marie-Tooth disease type 2D (CMT2D) [2].
However, Schimmel and his colleagues have now (http://www.pnas.org/content/early/2016/11/23/1617316113) discovered an aminoacyl tRNA synthetase called AlaRS that lacks any new decorations and can somehow still carry out its new role in humans without overhauling its basic architecture.
Physiocrines are derived from aminoacyl tRNA synthetases, which have been known for decades to function intracellularly in protein synthesis.
The top-half domain, sometimes referred to as a tRNA "minihelix," has been shown to provide the determinants necessary for specific charging by aminoacyl tRNA synthetases (14, 15); for interaction with elongation factor Tu (16); for 5[prime] processing by RNase P (17); and for distinguishing elongator from initiator tRNA (18).