amino acid sequence


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amino acid sequence

the order in which AMINO ACIDS are placed along a protein molecule (see PRIMARY STRUCTURE). Secondary and tertiary protein structure is highly dependent upon amino-acid sequence in the POLYPEPTIDE CHAIN, which affects the bonding together of the molecule. The ‘blueprint’ for this sequence is contained in DNA, whose bases contain the amino acid code; three bases provide the code for each amino acid. By the processes of TRANSCRIPTION and TRANSLATION the DNA-base sequence is mirrored in the amino-acid sequence, there generally being COLINEARITY between DNA and protein in PROKARYOTES. see Fig. 165 (FRAMESHIFT) for diagram.
References in periodicals archive ?
Amino Acid Sequence: The N-terminal amino acid sequence of purified globin chains was deduced by Edman degradation in an automated sequencer; model Procise 491 (Applied Biosystems).
Based on such research, Fujitsu Laboratories, the Insight Centre, and Fujitsu Ireland have now included not only structural information about amino acid sequences in the knowledge graph, but also chained information.
2004) and Expasy Bioinformatics Resource Portal (http://web.expasy.org.translate) for phylogenetic and amino acid sequence analysis respectively.
In this study, evolutionary trace (ET) method which relies on both amino acid sequence and structural information to analyze functional sites of proteins is used because of the advantage of having molecular and structural information in a single analysis 11].
The phylogenetic tree map was drawn by DNAMAN software on the basis of amino acid sequence of GAPDH in 6 species.
An example of amino acid sequence similarity resulting from sequence comparisons across biology is represented in Figure 1.
Scientists are creating these variants by modifying the amino acid sequence of brazzein.
For example, 97 percent of the amino acid sequence in human collagen matches that of the cow.
Table 1: ICH Topic Q6 B (Specifications: test procedures and acceptance criteria for biotechnological/biological products) Appendix for Physiochemical Characterization Structural characterization and confirmation a) Amino acid sequence b) Amino acid composition c) Terminal amino acid sequence d) Peptide map e) Sulfhydryl groups and disulphide bridges f) Carbohydrate structure Physicochemical properties --Molecular weight or size --Isoform pattern --Extinction coefficient --Electrophoretic patterns --Liquid chromatographic patterns --Spectroscopic profiles
When operated in ETD mode, the instrument provides extensive and easy-to-interpret amino acid sequence information in the form of complementary c- and z-series ions.