The top 20 pathways with significant enrichment among DEGs are shown in Figure 4 (p<0.05), and mainly included amino acid metabolism
, oxidative phosphorylation, lipid metabolism and pathways associated with certain diseases (e.g., Parkinson's disease and malaria).
Errors in amino acid metabolism
conclude some correlations between biochemical and pathological conditions, for example, alkaptonuria, an inherited metabolic disorder is caused by the absence of enzyme homogentisate oxidase due to which accumulation of homogentisate occurs and is excreted in urine, which turns dark black on standing due to oxidation.
Both aspartic and glutamic acid is a major precursor to many other amino acids (Azevedo et al., 2006) including isolucience and glycine and its accumulation may represent an important shift in amino acid metabolism
for enhanced stress tolerance.
Because healthy cells do not depend on amino acid metabolism
, venetoclax killed leukemia stem cells without harming healthy cells.
A molecular model of human branched-chain amino acid metabolism
. Am J Clin Nutr 1998; 68: 72-81.
Amino acid metabolism
pathways were also altered during treatment of AD rat models including alanine, aspartate and glutamate metabolism and cysteine and methionine metabolism.
Glutaric aciduria; a "new" disorder of amino acid metabolism
. Biochem Med 1975;12:12-21.
The proportion of metabolites involved bile acid metabolism, fatty acid metabolism, and amino acid metabolism
in the metabolism was the highest.
Inborn metabolic disorders affecting amino acid metabolism
are generally rare but are, by their very nature, complex and challenging conditions.
Alterations in cellular bioenergetics, amino acid metabolism
, and lipid metabolism have been shown to affect cytokine production, signaling protein activity, and cell differentiation [17-19].