ASPEN(redirected from American Society of Parenteral and Enteral Nutrition)
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ASPENAtorvastatin/Lipitor™ Study for the Prevention of coronary heart disease Endpoints in Non-insulin dependent diabetes mellitus. A trial comparing atorvastatin to placebo in reducing morbidity and mortality in type 2 diabetics ± previous myocardial infarction (MI).
Primary endpoints Cardiovascular disease-related death, nonfatal MI, nonfatal stroke, recanalization, CABG surgery, resuscitated cardiac arrest, and worsening or unstable angina.
Conclusion Despite a mean 29% reduction in the levels of LDL cholesterol in the atorvastatin group, no significant reduction in the rate of the primary end point; these results are discordant with the findings of other studies assessing statins in diabetics, which may have been related to changes in treatment guidelines during the study.
American Society for Parenteral and Enteral Nutrition.