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(konn-droy-tinn) ,

chondroitin polysulfate

(trade name),


(trade name),


(trade name)


Therapeutic: nonopioid analgesics
OsteoarthritisIschemic heart diseaseHyperlipidemiaOsteoporosis Ophthalmic: In combination with sodium hyaluronate, for use as a surgical aid in cataract extraction or lens implantation, and as a lubricant


May serve as a building block of articular cartilage. May protect cartilage against degradation. May have antiatherogenic properties.

Therapeutic effects

Improvement in osteoarthritis symptoms.


Absorption: 8–18% is absorbed orally.
Distribution: Unknown.
Metabolism and Excretion: Unknown.
Half-life: Unknown.

Time/action profile



Contraindicated in: Obstetric: Pregnancy and lactation.
Use Cautiously in: Asthma (may exacerbate symptoms); Clotting disorders (may ↑ risk of bleeding); Prostate cancer (may ↑ risk of metastasis or recurrence).

Adverse Reactions/Side Effects


  • heartburn
  • nausea
  • diarrhea


  • bleeding (antiplatelet effect)


  • allergic reactions
  • edema
  • hair loss


Use of chondroitin with anticoagulant and antiplatelet drugs, thrombolytics, NSAIDs, some cephalosporins, and valproates may ↑ risk of bleeding.Herbs with anticoagulant or antiplatelet properties may ↑ bleeding risk when combined with chondroitin, including: anise, arnica, chamomile, clove, dong quai, fenugreek, feverfew, ginger, ginkgo, Panax ginseng, licorice, and others.
Oral (Adults) Osteoarthritis—200–400 mg 2–3 times daily or 1000–1200 mg once daily. Prevention of recurrent myocardial infarction—10 grams daily in 3 divided doses for 3 mo followed by 1.5 grams daily in 3 divided doses as maintenance therapy.
Intramuscular (Adults) Osteoarthritis—50 mg twice weekly for 8 weeks every 4 mo.


Tablets: OTC
Capsules: OTC
Injection (not available in US):
Ophthalmic Drops Rx in combination with sodium hyaluronate (Viscoat):

Nursing implications

Nursing assessment

  • Evaluate drug profile before starting therapy with this herbal supplement. If the patient is taking anticoagulants or antiplatelet drugs, avoid use of this herb.
  • Monitor pain (type, location and intensity) and range of motion on an ongoing basis as an indicator of drug efficacy.
  • Evaluate gastric discomfort and instruct patient to seek out the advice of a health care professional if persistent gastric discomfort occurs.
  • Assess for signs of bleeding and discontinue herbal supplement promptly and seek out healthcare professional for follow up.

Potential Nursing Diagnoses

Chronic pain (Indications)
Impaired physical mobility (Indications)


  • Administer with food.

Patient/Family Teaching

  • Advise patients that this herbal supplement is usually taken with glucosamine.
  • Caution patients who take aspirin or NSAIDs or other nonprescription medications not to take this herbal supplement without conferring with their health care professional.
  • Advise female patients to notify health care professional if pregnancy is planned or suspected or if breastfeeding; avoid use.
  • Instruct patients that this medication works by building up cartilage and that this requires that the medication be taken consistently over a period of time. It is not recommended as a supplemental pain medication.

Evaluation/Desired Outcomes

  • Improvement in pain and range of motion.
  • Reduced need for supplemental or breakthrough pain medication.


Abbreviation for:
Carroll Depression scales
chemical (drug) delivery system
clonidine displacing substance
coding sequence
Commissioning Data Set, see there (Medspeak-UK)
community dental service (Medspeak-UK)
compliance data system
contract data set (Medspeak-UK)
controlled drug substance, see there


Controlled Drug Substance, see there.
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