amatoxin

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am·a·tox·in

(am-a-tok'sin),
One of a group of bicyclic octapeptides from death-cap fungus and deadly agaric (Amanita phalloides).

amatoxin

Toxicology Any of a family of potentially lethal toxins present in certain mushrooms—Amanita phalloides, Lepiota chlorophyllum and others, which may cause accidental poisoning in amateur mycophagists Clinical 12-hr latency, then N&V, abdominal pain, and diarrhea, which may be followed by an asymptomatic period before acute hepatic dysfunction and death Treatment Charcoal hemoperfusion

amatoxin

(am″ă-tok′sin) [ ama(nita) + toxin]
The chemical component of poisonous mushrooms that causes early onset of gastrointestinal upset. Liver failure follows about 36 hr later
References in periodicals archive ?
Octreotide, by preventing emptying of the gallbladder, might reduce recirculation of amatoxins in bile to the liver.
Prompt identification of mushroom-related toxic symptoms in the ED and early, aggressive IV volume replacement are critical first steps in diminishing the significant morbidity and mortality associated with amatoxin ingestion.
Legalon[R] SIL: the antidote of choice in patients with acute hepatotoxicity from amatoxin poisoning.
dagger]) Silibinin dihemisuccinate, a milk thistle extract, competitively inhibits hepatic amatoxin uptake and enterohepatic recycling, and is available in the United States through an open clinical trial.
Furthermore, during pregnancy, amatoxins do not cross the placental barrier, even during the acute phase of intoxication (10).
Amatoxins, phallotoxins, phallolysin and antamanide: the biologically active components of poisonous Amanita mushrooms.
Amatoxins kinetics in Amanita phalloides poisoning [Abstract].
Unfortunately, these mushrooms have no unique smell or taste characteristics, and cooking does not destroy the two types of cyclic oligopeptide toxins, the amatoxin and the phallotoxins.
Indication of liver transplantation following amatoxin intoxication.