amatoxin

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am·a·tox·in

(am-a-tok'sin),
One of a group of bicyclic octapeptides from death-cap fungus and deadly agaric (Amanita phalloides).

amatoxin

Toxicology Any of a family of potentially lethal toxins present in certain mushrooms—Amanita phalloides, Lepiota chlorophyllum and others, which may cause accidental poisoning in amateur mycophagists Clinical 12-hr latency, then N&V, abdominal pain, and diarrhea, which may be followed by an asymptomatic period before acute hepatic dysfunction and death Treatment Charcoal hemoperfusion

amatoxin

(am″ă-tok′sin) [ ama(nita) + toxin]
The chemical component of poisonous mushrooms that causes early onset of gastrointestinal upset. Liver failure follows about 36 hr later
References in periodicals archive ?
* Octreotide, by preventing emptying of the gallbladder, might reduce recirculation of amatoxins in bile to the liver.
Prompt identification of mushroom-related toxic symptoms in the ED and early, aggressive IV volume replacement are critical first steps in diminishing the significant morbidity and mortality associated with amatoxin ingestion.
Legalon[R] SIL: the antidote of choice in patients with acute hepatotoxicity from amatoxin poisoning.
([dagger]) Silibinin dihemisuccinate, a milk thistle extract, competitively inhibits hepatic amatoxin uptake and enterohepatic recycling, and is available in the United States through an open clinical trial.
The lethal dose of the [alpha]-amanitin component is 0.1-0.3 mg/kg (8), and phallotoxins seem to exacerbate the action of amatoxins. [alpha]-Amanitin represents 0.2-0.4 mg of the amatoxins, which can reach concentrations as high as 5 mg/g of dry mass in A.
Amatoxins, phallotoxins, phallolysin and antamanide: the biologically active components of poisonous Amanita mushrooms.
Amatoxins kinetics in Amanita phalloides poisoning [Abstract].
Unfortunately, these mushrooms have no unique smell or taste characteristics, and cooking does not destroy the two types of cyclic oligopeptide toxins, the amatoxin and the phallotoxins.