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A highly toxic, heat-stable bicyclic oligopeptide in the mushroom Amanita phalloides. It inhibits transcription by certain RNA polymerases.
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An anti-CD117 amanitin ADC with engineered fast half-life showed potent stem cell depletion and rapid clearance, providing appropriate pharmacokinetics for patient preparation for bone marrow transplant.
Administration of cimetidine, a cytochrome P-450 inhibitor which inhibits the uptake of amatoxins by the mixed function oxidase system, and N-acetylcysteine (NAC), a glutathione precursor that binds amatoxin-related free radicals, have also been used in the treatment of amanitin intoxication.
Parasite pressure and the evolution of amanitin tolerance in Drosophila.
Non-Genotoxic Conditioning Using Amanitin Antibody-Drug Conjugates Targeting CD45 Effectively Deplete Human and Non-Human Primate Hematopoietic Stem Cells and Immune Cells:A single dose of an anti-CD45 ADC achieved efficient depletion of immune cells in the periphery and hematopoietic stem cells in the bone marrow in preclinical models.
The collaboration will combine Magenta's stem cell platform with proprietary antibodies across up to four exclusive targets with Heidelberg Pharma's proprietary antibody targeted amanitin conjugates (ATAC) platform.
Antibody Targeted Amanitin Conjugates (ATACs) and minorgroove binding DNA-interactive molecules as ADC payloads, to expand the ADC landscape
Previous studies have shown that mycophagous species of Drosophila can develop on medium containing amanitin concentrations at least an order of magnitude greater than the maximum doses that nonmycophagous species can tolerate (Jaenike et al.
Antibody Targeted Amanitin Conjugates (ATACs), principles for maximising the drug delivery efficiency and therapeutic index and using fragment conjugates in order to develop a tailored therapy for solid tumours.
The goal of the alliance is to discover and develop novel Antibody Targeted Amanitin Conjugates (ATACs) based on the technology of Heidelberg Pharma to couple ?-Amanitin to antibodies.
This book contains a section on amanitin, the major toxin for this class of mushroom.
Silymarine (from the milk thistle Silibum marianum) exerts its protective effect after intravenous administration in various ways: (a) by interrupting the enterohepatic recirculation of amanitin; (b) by inhibiting the binding of toxins to hepatocyte membranes; (c) by competing with amatoxin for transmembrane transport; and (d) by inhibiting the penetration of amanitin into liver cells (1).