Amadori rearrangement | definition of Amadori rearrangement by Medical dictionary
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Am·a·dor·i re·ar·range·ment (ă-mă-dōr'ē),
a rearrangement that occurs in cross-linking reactions seen in collagen and in protein glycosylations; for example, conversion of N-glycosides of aldoses to N-glycosides of the corresponding ketoses.
References in periodicals archive
This non-enzymatic process initially forms reversible early glycosylation products and later irreversible advanced glycosylation end-products (AGEs) via an Amadori rearrangement
Undergoes an Amadori rearrangement
, producing a ketoamine;
The aldehyde group of the glucose first forms a Schiff base with the NH2-terminal amino group, which then rearranges to a more stable amino ketone linkage by a spontaneous (nonenzymatic) reaction known as the Amadori rearrangement
When glucose reacts with hemoglobin (Hb), the first products are Schiff bases that slowly undergo Amadori rearrangement
to produce stable ketoamines (glycohemoglobin).