antacid

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antacid

 [ant-as´id]
1. counteracting acidity.
2. an agent that counteracts acidity; antacids are often used in the treatment of peptic ulcer. Substances that act as antacids include sodium bicarbonate, aluminum hydroxide gel, calcium carbonate, magnesium hydroxide, magnesium oxide, and magnesium trisilicate.

Since many substances used as medications are weak acids or weak bases, there is a high potential for drug-drug interaction involving antacids. Antacids can form insoluble complexes, interfere with drug absorption, and affect renal excretion of drugs by changing the pH of urine.

In the most commonly used antacids the main active agents are magnesium hydroxide and aluminum hydroxide. Magnesium hydroxide, or “milk of magnesia,” can produce diarrhea. Aluminum hydroxide and calcium carbonate are constipating. It may be necessary to alternate types of antacids when they are taken on a long-term basis. The sodium content varies; some antacids may contain as much as ten times more sodium than others. The sugar content of antacids must also be taken into account, particularly for patients with diabetes mellitus or those on a low-calorie diet. Some have no sugar, whereas others have a considerable amount.

ant·ac·id

(ant-as'id),
1. Neutralizing an acid.
2. Any agent that reduces or neutralizes acidity, as of the gastric juice or any other secretion (for example, calcium carbonate, magnesium hydroxide).
Synonym(s): antiacid

antacid

(ănt-ăs′ĭd)
adj.
Counteracting or neutralizing acidity, especially of the stomach.
n.
A substance, such as magnesia or sodium bicarbonate, that neutralizes acid.

antacid

A basic (i.e., pH < 7) agent that neutralises acid in the gastric lumen; the final pH achieved is usually a function of the amount of antacid administered.

GI effects
Antipeptic, increased in acid secretion, increased GI motility, increased mucus secretion; antacids vary in absorption (e.g., NaHCO3 and sodium citrate and are completely absorbed, which may result in metabolic acidosis).

antacid

Pharmacology A basic agent that neutralizes acid in the gastric lumen; the final pH achieved is usually a function of the amount of antacid administered GI effects Antipeptic, ↑ in acid secretion, ↑ GI motility, ↑ mucus secretion; antacids vary in absorption–eg, NaHCO3 and sodium citrate and are completely absorbed, which may result in metabolic acidosis

ant·ac·id

(ant-as'id)
1. Neutralizing an acid.
2. Any agent that reduces or neutralizes acidity, as of the gastric juice or any other secretion.

antacid

A drug used to combat excess stomach acid or to treat the symptom of ACID REFLUX. Antacid drugs are often compounds of magnesium or aluminium. Antacids may also provide a protective coating to the lining of the stomach and DUODENUM.

Antacid

A substance that counteracts or neutralizes acidity, usually of the stomach. Antacids have a rapid onset of action compared to histamine H-2 receptor blockers and proton pump inhibitors, but they have a short duration of action and require frequent dosing.

ant·ac·id

(ant-as'id)
Any agent that reduces or neutralizes acidity, as of the gastric juice or any other secretion (e.g., calcium carbonate, magnesium hydroxide).
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