aluminium phosphide


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aluminium phosphide

A pesticide used to fumigate stored grains and rodenticide. Poisoning is more common in farming communities; it is a popular and effective agent for committing suicide in India and Iran. When ingested, it reacts with gastric HCl releasing 1 g of phosphine (10 times its lethal dose), causing death in two hours.

Clinical features
Cardiovascular—arrhythmia, myocarditis, myocardial infarction, hypotensive shock, respiratory distress; GI—epigastric pain, pancreatitis, diarrhoea, vomiting; metabolic effects/chemical pathology—metabolic acidosis, hypercalcaemia, hypomagnesaemia, convulsions, liver failure, kidney failure.
 
Pathogenesis
Vascular damage, RBC membrane damage, cytochrome oxidase inhibition with mitochondrial dysfunction, end-organ hypoxia.

Mechanism
Generates phosphine gas (PH3) in contact with water.

Mortality
High.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Tests confirmed the use of banned aluminium phosphide, which can cause heart inflammation and multi-organ failure.
Sharjah: Sharjah Municipality have warned the public against using the services of unlicensed pesticide companies in the wake of a 10-year-old Pakistani boy's death from aluminium phosphide poisoning in Al Nahda on Friday.
In his scrutiny note of the charge sheet, the prosecutor had argued that suspects were found involved in deliberate use of the poisonous substance ie aluminium phosphide tablets in the guest house's room, where the family stayed, adding that the killing of the six people had terrorised the public.
DIG Kharal said that when the investigation teams searched Qasr-e-Naz, they found empty bottles of Aluminium Phosphide in its store.
The letter asks the executive engineer to provide the relevant record pertaining to the supply of Aluminium Phosphide. It also sought details regarding the responsibilities of various officials, including the sub-engineer, assistant executive engineer, executive engineer and superintending engineer.
Sheikh suggested that the police should also consider the incident of death of 6 family members in Karachi due to aluminium phosphide which was an insecticide spray.
Separately, the minister for agriculture Ismail Rahu said it would be premature to ascertain that five children and their aunt died due to Aluminium Phosphide which had been used as insecticides in their room.
KARACHI -- The chemical examination report stated that the deaths in the family from Pishin were caused by Aluminium Phosphide poisoning.
This chemical has various technical and industrial applications.Aluminium silicate, aluminium phosphide and poly aluminium chloride are other aluminium chemicals which are used in textile, paper and medical industry among others.
The highest number of deaths (7/16, 43.75%) were observed in the aluminium phosphide (wheat pill) poisoning patients which was followed by organophosphorus poisoning (4/40, 10%).
A forensic examination of the bodies of her parents revealed the acute presence of aluminium phosphide, a poisonous substance, which is commonly used in pesticides and rat poison in India.