Line-mediated retrotransposition of marked Alu sequences
. Nat Genet 2003;35:41-8.
The non-coding regions are characterized by many types of repeated DNA sequences, where 10.6% consists of Alu sequences
, a type of SINE (short and dispersed repeated elements) sequence and preferentially located towards the genes.
Osenberg et al., "Alu Sequences
in Undifferentiated Human Embryonic Stem Cells Display High Levels of A-to-I RNA Editing," PLOS One 5, no.
Together, the LINE and ALU sequences
comprise approximately 30% of the genome (Miki 1998).
Our data also showed that the distribution of the genomic variables included in this study (genes, CpG islands, SNPs, and Alu sequences
), was different for each ofthe DSCR genes; with the DSCR2 gene showing greater variation.
are short stretches of DNA with the unusual ability to copy themselves and jump from one chromosome to another.
PCR primers were designed toward consensus LINE-1 and Alu sequences
and allowed for the amplification of a representative pool of repetitive elements to serve as a surrogate for diffuse genomic DNA methylation changes.
In view of the complexity of the premature stop codon mutations in NF1 , the existence of 7 pseudogenes and pseudogene sequences on different chromosomes, and the fact that this gene consists of 58 exons and harbors complex genomic structures, such as repetitive sequences and Alu sequences
, NF1 is an ideal clinical target for evaluating the effectiveness of the SCE-NGS method for clinical applications (24,26-29).
Tens of thousands of Alu sequences
lace the human genome, but their functions remain unknown.
The breakpoints involved alu sequences
, because it has been reported for other BRCA1 deletions (19).
Human Cytochrome P450 4 mRNA and gene: part of a multigene family that contains Alu Sequences
in its mRNA.