"One novelty of this work is that we looked at genetic variants that operate through alternative splicing
rather than just the total abundance of a gene, which led us to genes we would not have otherwise identified, including one validated experimentally.
In agreement with this finding, HNRNPs have been commonly implicated in alternative splicing
that favors the survival of malignant cells.
The high incidence of alternative splicing
(AS) in plants (found in >600% of intron-containing genes) requires methods to distinguish and quantify AS variants or isoforms.
The LAMP-2 protein has three distinct variants generated by alternative splicing
: LAMP-2A, LAMP-2B and LAMP-2C.
Skyhawk's SkySTAR (Skyhawk Small molecule Therapeutics for Alternative splicing
of RNA) platform to build small molecule drugs that deliver breakthrough treatments.
Ihab Younis, assistant professor of biological sciences, and Ettaib El Marabti, a 2017 graduate of CMU-Q's Biological Sciences Program, authored a paper in Frontiers in Molecular Biosciences titled 'The cancer spliceome: Reprogramming of alternative splicing
Ihab Younis, assistant professor of biological sciences, and Ettaib El Marabti, a 2017 graduate of CMU-Q's Biological Sciences Programme, authored a paper in 'Frontiers in Molecular Biosciences', titled "The cancer spliceome: Reprogramming of alternative splicing
with less than 5% reads were filtered out.
In the current study on birds, we found that all 3 opioid receptor genes for the 3 birds studied undergo alternative splicing
, as is seen for the mouse, (23) rat, (24) and human.
Three of these segments use alternative splicing
to produce two essential viral proteins each, which are important in helping the virus gain entry into host cells.
'So basically, we have made the connection between the process of alternative splicing
and the development of this system that coordinates heart contraction and function,' Cooper added.
The team of researchers identified the CELF1 protein as being responsible for regulating certain alternative splicing
events, Cooper said.So by turning on and off CELF1 expression at different points in development, researchers were able to see how the protein affects development during this stage.