alternative complement pathway

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a course usually followed. In neurology, the nerve structures through which a sensory impression is conducted to the cerebral cortex (afferent pathway), or through which an impulse passes from the brain to the skeletal musculature (efferent pathway). Also used alone to indicate a sequence of reactions that convert one biological material to another (metabolic pathway).
accessory pathway (accessory conduction pathway) extra muscle tissue between the atrium and ventricle that bypasses all or part of the normal conduction system. When the ventricles are activated prematurely via this pathway, initial forces are slow, producing the delta wave of wolff-parkinson-white syndrome, and preexcitation is said to exist; the delta wave causes the PR interval to shorten and the QRS interval to broaden.
alternative complement pathway see complement.
amphibolic pathway a group of metabolic reactions with a dual function, providing small metabolites for further catabolism to end products or for use as precursors in synthetic, anabolic reactions. The tricarboxylic acid cycle is an example. See also anabolism and catabolism.
biosynthetic pathway the sequence of enzymatic steps in the synthesis of a specific end-product in a living organism.
classical complement pathway see complement.
common pathway of coagulation the steps in the mechanism of coagulation (see clotting) from the activation of factor x through the conversion of fibrinogen to fibrin. See also intrinsic pathway of coagulation and extrinsic pathway of coagulation.
concealed accessory pathway an accessory pathway that has only retrograde conduction; thus its PR and QRS complexes are normal on the electrocardiogram, but there is a tendency to develop premature supraventricular tachycardia. If atrial fibrillation develops, conduction will proceed across the atrioventricular node.
Embden-Meyerhof pathway the series of enzymatic reactions in the anaerobic conversion of glucose to lactic acid, resulting in energy in the form of adenosine triphosphate (ATP).
extrinsic pathway of coagulation the mechanism that produces fibrin following tissue injury, beginning with formation of an activated complex between tissue factor and factor vii and leading to activation of factor x, which induces the reactions of the common pathway of coagulation. See also intrinsic pathway of coagulation.
final common pathway
1. the motor neurons by which nerve impulses from many central sources pass to a muscle or gland in the periphery.
2. any mechanism by which several independent effects exert a common influence.
intrinsic pathway of coagulation a sequence of reactions leading to fibrin formation, beginning with the contact activation of factor xii. This is followed by the sequential activation of factors xi and ix, which results in the activation of factor x. Activated factor X (factor Xa) initiates the common pathway of coagulation. See also extrinsic pathway of coagulation.
pentose phosphate pathway a pathway of hexose oxidation in which glucose-6-phosphate undergoes two successive oxidations by NADP, the final forming a pentose phosphate.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

alternative complement pathway

Properdin pathway Immunology A route of complement activation that occurs independently of complement-fixing antibodies; the ACP is more complex than the classic complement pathway; it requires a 'priming' C3 convertase–C3,Bb, and an 'amplification' C3 convertase–C3b,Bb; in the presence of properdin, C3 convertase is stabilized, activating later complement components, which leads to opsonization, leukocyte chemotaxis, ↑ vascular permeability, and cytolysis; ACP is activated by properdin, IgA, IgG, lipopolysaccharide, and snake venom; both pathways are stimulated by trypsin-like enzymes. Cf Complement.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Swift's "alternate pathway" likely is the FAA's supplemental type certificate (STC) process, which General Aviation Modifications, Inc.
The 52-week study is designed to enroll patients with late-onset disease who are clinically stable and on a stable dose of alternate pathway medication.
leprae infection and may be an alternate pathway for bacillary clearance both in the early and later stages of infection.
'Our approach is to provide an alternate pathway to people and unleash their untapped potential to help change the landscape not just for them but also their communities.
In doing so, this medication, classed as an antisense oligonucleotide (ASO), can reduce serum LDL cholesterol using an alternate pathway than the statins and PCSK9 inhibitors.
This alternate pathway can account for almost 15-20% of the incident CRCs and majority of the interval cancers after a screening colonoscopy [7,8].
For a long time, this alternate pathway, which emphasized practical working skills, was regarded as the more suitable option for lower-achieving students.
"Cisplatin goes through the p16 and p53 pathways, while the curcumin uses an alternate pathway," said Dr.
And it wants the reactor converted to reduce to a minimum its production of plutonium, an alternate pathway to nuclear arms.
The microsomal ethanol oxidizing system (MEOS), which is generated by hepatocytes and hepatic enzymes including CYP2E1, CYP1A2, and CYP3A, is an alternate pathway for ethanol metabolism (Lieber 1999; Garcia-Banuelos et al.
The alternate pathway functions in an antibody independent route and thus does not require prior exposure to a particle for activation.
If a team member or partner suggests an alternate pathway to the summit, or if we run into a brick wall in the path we're on, can we be creative and flexible enough to find another way, while progressing ever upwards?

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